🚀 go-pugleaf

I unfortunately think you pretty well characterized the dilemma
between fighting the virus by natural pathways or taming the allergy.
I do hope however that our immune system has more resources than we
know of and maybe one day we'll find the right switches (there was an
article about the Wistar Institute and T-cell receptors in Science
Daily today on that).

Note that while HHV6 can integrate into the genes, it doesn't
necessarily need to do that to survive inside a host. Many pathogens
have intracellular survival capacity, and once they find a nice
resting place inside a cell, they can stay dormant or partially so
indefinitely. I remember a picture in a magazine article where they
had managed to spot viruses hiding inside small vesicles that could
clearly be seen inside a cell's mitochondria - which means by the way
that these vesicles can resist the intense oxydation going on there.
Maybe not every intracellular pathogen can do that, but still, there
are pathogens that are probably not possible to get rid of. All the
more so if they manage to integrate into the genome. Also, viruses can
benefit from/integrate bacterial biofilms, where protection is also
good.

I think I read HHVs are ubiquitous, with maybe everyone harboring at
least one member of the family. In a majority of individuals, they
stay dormant most of the time, meaning that the immune system does a
good job of keeping them silenced. Even if you could get totally rid
of one, you would probably get recontaminated the next day by another
one, so the best thing would be to do like every healthy person : get
your immune system to contain them permanently. Easier said than done,
but I think this has to be the only logical answer.

What about trying to raise the glutathione levels to force the
immunity to act ? This is not very obvious to do apparently, but maybe
this path can be explored at least.

What do you mean exactly by low D3 levels (what range?) even after
supplementation (how much for how long and what type : D2 or D3) ?
Have you checked if your kidneys are ok ? Are your Calcium and
Phosphorus "balances" in equilibrium ? Do you take something that
interferes with the vitamin D metabolism or its receptor ?

On Nov 30, 8:21 pm, Kofi <k...@anon.un> wrote:
> What follows is a quick condensation of research I've been posting in
> places like sci.life-extension and alt.support.crohns-colitis over the
> years.  It's a novel synthesis of recently published research.
>
> I've had mercury poisoning from a cracked filling, severe autoimmunity -
> I react to all but a few foods now - severe TMJ/bruxism and neuropathy
> (that I now know was caused by the shingles) and nutritional
> deficiencies that have all required years to treat.  I've always had
> some mild problems with allergies and sinusitis but things slid downhill
> quickly when I received four amalgam fillings.
>
> This last September, on a hunch my doctor ran a panel for herpesviruses.  
> I came back positive for three of the six tested (HHV5
> (cytomegalovirus), HHV6, HHV3 (Varicella zoster)).  Once I dug deeper, I
> began to realize how central these viruses were to my problems.  CMV
> causes colitis and interferes with vitamin D3 (via IL-10).  Varicella
> zoster causes chicken pox and the shingles.  HHV6 is linked to chronic
> fatigue and epilepsy.
>
> I increasingly lean toward the conclusion that herpesviruses cannot be
> separated from my personal problems with yeast (intolerance increases as
> IDO levels drop), TMJ/neuropathy (via trigeminal nerve damage [PMID
> 17881451]), metals poisoning and autoimmunity (low IL-10 signaling).  At
> this point, a persistent viral infection is the only thing that
> perfectly explains my ongoing symptoms.  Despite the butyrate and
> despite the helminths (www.ovamed.de) and despite all the other
> treatments, while my health has improved dramatically my general
> symptoms still persist.  Indeed, the metals exposure may have damaged my
> immune system enough to allow the viruses to reawaken [PMID 8931761,
> 8686573, 7526487] which then lowered my growth hormone levels in the
> affected areas [PMID 8686573] leading to, for instance, joint erosion in
> the TMJ and nutritional deficiency similar to that seen in short bowel
> syndrome.
>
> Because of the way butyrate and its HDAC inhibition benefit the herpes
> family [PMID 18753203, 18653451], I believe the body may actually create
> colitis with CMV infections by turning off butyrate uptake via
> downregulation of carnitine transporter OCTN2/Atb0+.  I posted an
> article on this a long time ago [PMID 17065219].  Inflammatory insults
> seem to lower OCTN2/Atb0+ and genetic defects in this transporter
> predispose someone to autoimmune digestive disorders.
>
> If so, I would be trapped in a catch-22 by taking butyrate to relieve my
> symptoms - at least until the viruses are cleared out.
>
> Good theories are supposed to explain events you've witnessed and
> predict future behavior when variables change, giving you an idea of how
> to improve life.  I think my viral hypothesis does exactly this.  To
> recap my prior postings, the metabolic chain at issue runs something
> like this.
>
> PPARalpha agonists (e.g., oleic acid in olive oil, rapamycin [PMID
> 15769938], green tea, fibrates (fenofibrate), resveratrol, pterostilbene
> (in blueberries), clofibrate/Atromid-S [PMID 17644405]; intermittent
> fasting [PMID 18309235, 18926685]) ->
>
> OCTN2 upregulated (where the viral interference comes into play) ->
>
> enhanced carnitine uptake (inhibiting PKC and thus raising the pain
> threshold; blocking PKC also helps with insulin resistance, opiate
> tolerance/mu opioid receptor desensitization, diabetes and maybe even
> leaky gut; high G.I. diets raise PKC; homocysteine also raises PKC so B
> vitamins are helpful; homocysteine blocks GABA channels... you begin to
> see how the viruses trip all sorts of pathways that lead to perception
> of chronic pain; DHEA also blocks PKC) ->
>
> enhanced butyrate uptake ->
>
> increased HDAC inhibition, yielding more acetylated histones ->
>
> HDAC inhibition gives us...
>
> + mu opioid receptor upregulation and stimulation of cannabinoid
> signaling (which I also get from low-dose naltrexone; I suspect the
> cannabinoids limits B cell proliferation which then limits the risk of
> autoimmunity)
>
> + greater metallothionein expression to move metals out of the body
> (which I get help with from molybdenum supplements; see my prior
> postings on Coxsackie, cardiomyopathy, metals accumulation and HDACs)
>
> + IDO expression (leading to more tolerance of yeast; IDO is blocked by
> tryptophan which might be why you don't want to over do it on the turkey
> this weekend; note that butyrate also inhibits chitin production in the
> body's yeast colonies and conditions like sinusitis involve genetically
> enhanced sensitivity to chitin [PMID 16871939])
>
> + more FoxP3/Tregs (what the helminths are supposed to do with IL-10;
> PKC also affects Treg function; see my recent posting on IgG4)
>
> + more autophagy (related to ketone metabolism and valuable for
> infection-fighting; this is also defective in Crohn's (ATG16L1); I
> wonder if the viruses create general defects in ketone metabolism that
> makes epilepsy more likely)
>
> + lower TNF-alpha (via PPARalpha agonism, the Tregs and probably other
> pathways)
>
> You can see how various treatments I've tried all fit neatly somewhere
> on this metabolic chain.  Not only that, but you can see how various
> other conditions like Crohn's, M.S. - even cardiomyopathy - are related
> and benefit from similar treatments.  These conditions not so
> coincidentally have connections to viral infections that affect HDACs
> (herpesviruses like Epstein-Barr in M.S., Coxsackie virus B3 in
> cardiomyopathy).
>
> We need an antiinflammatory approach to treat our symptoms but if you
> don't know why your body is inflamed, interference can be
> counterproductive.  Blocking COX-2 blocks Tregs, the breaks on
> autoimmunity/allergy.  Blocking leukotrienes to get at the allergy
> symptoms then blocks a crucial immune response directed against the
> viruses [PMID 17931111].  Glucocorticoids also pose similar problems
> because then you lose cathelicidin, another antimicrobial/antiviral
> [PMID 18424743].  What we need to do is force a resolution of the
> inflammation and if you've got a viral infection causing it all, the
> best way to resolve that is kill the virus.
>
> Unfortunately for me - and I hate to drop this bombshell - but my HHV6
> virus may have permanently integrated itself into my genes.  Yes, the
> little bastard can do that.
>
> The one remaining mystery for me is why my vitamin D3 levels remain
> persistently low despite shots and oral supplements.  The only thing
> that seems to work is constant sun exposure.  I suspect the viruses at
> work, but I have no lead at them moment.  If anyone's come across any
> relevant information, I'd love to hear it.

There's your cure: a long holiday in a sunny place without internet
access.

--
Joe

Kofi,

re vitamin D absorption

http://heartscanblog.blogspot.com/search/label/Vitamin%20D%20disappointment%20ahead

-- 

"J.A.Legris" <jalegris@sympatico.ca> wrote in message 
news:f32c71eb-612f-4609-a7fa-7b5ebc432228@f13g2000yqj.googlegroups.com...
On Nov 30, 8:21 pm, Kofi <k...@anon.un> wrote:
> What follows is a quick condensation of research I've been posting in
> places like sci.life-extension and alt.support.crohns-colitis over the
> years. It's a novel synthesis of recently published research.
>
> I've had mercury poisoning from a cracked filling, severe autoimmunity -
> I react to all but a few foods now - severe TMJ/bruxism and neuropathy
> (that I now know was caused by the shingles) and nutritional
> deficiencies that have all required years to treat. I've always had
> some mild problems with allergies and sinusitis but things slid downhill
> quickly when I received four amalgam fillings.
>
> This last September, on a hunch my doctor ran a panel for herpesviruses.
> I came back positive for three of the six tested (HHV5
> (cytomegalovirus), HHV6, HHV3 (Varicella zoster)). Once I dug deeper, I
> began to realize how central these viruses were to my problems. CMV
> causes colitis and interferes with vitamin D3 (via IL-10). Varicella
> zoster causes chicken pox and the shingles. HHV6 is linked to chronic
> fatigue and epilepsy.
>
> I increasingly lean toward the conclusion that herpesviruses cannot be
> separated from my personal problems with yeast (intolerance increases as
> IDO levels drop), TMJ/neuropathy (via trigeminal nerve damage [PMID
> 17881451]), metals poisoning and autoimmunity (low IL-10 signaling). At
> this point, a persistent viral infection is the only thing that
> perfectly explains my ongoing symptoms. Despite the butyrate and
> despite the helminths (www.ovamed.de) and despite all the other
> treatments, while my health has improved dramatically my general
> symptoms still persist. Indeed, the metals exposure may have damaged my
> immune system enough to allow the viruses to reawaken [PMID 8931761,
> 8686573, 7526487] which then lowered my growth hormone levels in the
> affected areas [PMID 8686573] leading to, for instance, joint erosion in
> the TMJ and nutritional deficiency similar to that seen in short bowel
> syndrome.
>
> Because of the way butyrate and its HDAC inhibition benefit the herpes
> family [PMID 18753203, 18653451], I believe the body may actually create
> colitis with CMV infections by turning off butyrate uptake via
> downregulation of carnitine transporter OCTN2/Atb0+. I posted an
> article on this a long time ago [PMID 17065219]. Inflammatory insults
> seem to lower OCTN2/Atb0+ and genetic defects in this transporter
> predispose someone to autoimmune digestive disorders.
>
> If so, I would be trapped in a catch-22 by taking butyrate to relieve my
> symptoms - at least until the viruses are cleared out.
>
> Good theories are supposed to explain events you've witnessed and
> predict future behavior when variables change, giving you an idea of how
> to improve life. I think my viral hypothesis does exactly this. To
> recap my prior postings, the metabolic chain at issue runs something
> like this.
>
> PPARalpha agonists (e.g., oleic acid in olive oil, rapamycin [PMID
> 15769938], green tea, fibrates (fenofibrate), resveratrol, pterostilbene
> (in blueberries), clofibrate/Atromid-S [PMID 17644405]; intermittent
> fasting [PMID 18309235, 18926685]) ->
>
> OCTN2 upregulated (where the viral interference comes into play) ->
>
> enhanced carnitine uptake (inhibiting PKC and thus raising the pain
> threshold; blocking PKC also helps with insulin resistance, opiate
> tolerance/mu opioid receptor desensitization, diabetes and maybe even
> leaky gut; high G.I. diets raise PKC; homocysteine also raises PKC so B
> vitamins are helpful; homocysteine blocks GABA channels... you begin to
> see how the viruses trip all sorts of pathways that lead to perception
> of chronic pain; DHEA also blocks PKC) ->
>
> enhanced butyrate uptake ->
>
> increased HDAC inhibition, yielding more acetylated histones ->
>
> HDAC inhibition gives us...
>
> + mu opioid receptor upregulation and stimulation of cannabinoid
> signaling (which I also get from low-dose naltrexone; I suspect the
> cannabinoids limits B cell proliferation which then limits the risk of
> autoimmunity)
>
> + greater metallothionein expression to move metals out of the body
> (which I get help with from molybdenum supplements; see my prior
> postings on Coxsackie, cardiomyopathy, metals accumulation and HDACs)
>
> + IDO expression (leading to more tolerance of yeast; IDO is blocked by
> tryptophan which might be why you don't want to over do it on the turkey
> this weekend; note that butyrate also inhibits chitin production in the
> body's yeast colonies and conditions like sinusitis involve genetically
> enhanced sensitivity to chitin [PMID 16871939])
>
> + more FoxP3/Tregs (what the helminths are supposed to do with IL-10;
> PKC also affects Treg function; see my recent posting on IgG4)
>
> + more autophagy (related to ketone metabolism and valuable for
> infection-fighting; this is also defective in Crohn's (ATG16L1); I
> wonder if the viruses create general defects in ketone metabolism that
> makes epilepsy more likely)
>
> + lower TNF-alpha (via PPARalpha agonism, the Tregs and probably other
> pathways)
>
> You can see how various treatments I've tried all fit neatly somewhere
> on this metabolic chain. Not only that, but you can see how various
> other conditions like Crohn's, M.S. - even cardiomyopathy - are related
> and benefit from similar treatments. These conditions not so
> coincidentally have connections to viral infections that affect HDACs
> (herpesviruses like Epstein-Barr in M.S., Coxsackie virus B3 in
> cardiomyopathy).
>
> We need an antiinflammatory approach to treat our symptoms but if you
> don't know why your body is inflamed, interference can be
> counterproductive. Blocking COX-2 blocks Tregs, the breaks on
> autoimmunity/allergy. Blocking leukotrienes to get at the allergy
> symptoms then blocks a crucial immune response directed against the
> viruses [PMID 17931111]. Glucocorticoids also pose similar problems
> because then you lose cathelicidin, another antimicrobial/antiviral
> [PMID 18424743]. What we need to do is force a resolution of the
> inflammation and if you've got a viral infection causing it all, the
> best way to resolve that is kill the virus.
>
> Unfortunately for me - and I hate to drop this bombshell - but my HHV6
> virus may have permanently integrated itself into my genes. Yes, the
> little bastard can do that.
>
> The one remaining mystery for me is why my vitamin D3 levels remain
> persistently low despite shots and oral supplements. The only thing
> that seems to work is constant sun exposure. I suspect the viruses at
> work, but I have no lead at them moment. If anyone's come across any
> relevant information, I'd love to hear it.

There's your cure: a long holiday in a sunny place without internet
access.

--
Joe