Thread View: alt.support.cancer
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Started by kaptan
Fri, 12 Sep 2008 07:58
Melanoma, ALS, Parkinson's, Riluzole and Glutamate
Author: kaptan
Date: Fri, 12 Sep 2008 07:58
Date: Fri, 12 Sep 2008 07:58
96 lines
5741 bytes
5741 bytes
Study Shows Riluzole Shrinks Tumors Without Toxic Side Effects http://www.webmd.com/melanoma-skin-cancer/news/20080415/als-drug-slows-melan oma-growth Riluzole early phase 1 trial recruiting now http://clinicaltrial.gov/ct2/show/NCT00667901?intr=%22Riluzole%22&rank=7 Riluzole $10 a pill http://www.assetchemist.co.uk/Product_Details.php?product_id=318023 Lou Gehrig's Disease forum http://www.als.net/forum/topic.asp?TOPIC_ID=2807 2007 - Metabotropic Glutamate Receptor 1 and Glutamate Signaling in Human Melanoma http://cancerres.aacrjournals.org/cgi/content/full/67/5/2298 Riluzole Wiki http://en.wikipedia.org/wiki/Riluzole A common feature to both ALS and melanoma cells is excess glutamate. Grm1 -- responsible for melanoma in laboratory mice. Its normal functions are in the brain, where it is associated with learning and memory; but when this gene is expressed or turned on in certain skin cells, it leads to the development of melanoma. In a melanoma cell, the glutamate enters a pernicious loop where it binds to the malfunctioning cell surface protein. The protein operates as a receptor, stimulating the cell to produce more glutamate that, in turn, binds to the receptor, stimulating more production. This cellular "overfeeding" results in the growth and expansion of the melanoma. http://www.sciencedaily.com/releases/2008/04/080415164326.htm Google Book - Glutamate release inhibitors http://books.google.com.au/books?id=scXBq7jBxo0C&pg=PA40&lpg=PA40&dq=glutama te+release+inhibitors&source=web&ots=D4HxR0rXxs&sig=yj_sF1Aui0o6YZErfV0nYBQf DlA&hl=en&sa=X&oi=book_result&resnum=10&ct=result#PPA38,M1 If skin, neuronal and bone cells have glutamate receptors then could this be a mechanism whereby damp air aggravates arthritis? http://www.fasebj.org/cgi/content/full/15/9/1586 1997 Google Book - Glutamate in Helath and Disease http://books.google.com.au/books?hl=en&lr=&id=Vg4sg_ivdlUC&oi=fnd&pg=PA87&dq =%22Holt%22+%22Glutamate+in+Health+and+Disease:+The+Role+of+Inhibitors%22+&o ts=2NWII1hMOh&sig=niTvQooFXrqOBvO5T5OxQIGWqEs#PPA87,M1 Higher incidence of melanoma in Parkinson's but not due to levodopa http://www.ncbi.nlm.nih.gov/pubmed/17373726?ordinalpos=8&itool=EntrezSystem2 .PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum ... due to glutamate? "Our results suggest a decreased incidence of most cancers in patients with PD. PD patients had a significantly increased risk of malignant melanoma, a finding consistent with prior studies. " http://cebp.aacrjournals.org/cgi/content/full/16/6/1260 "Both ALS and Parkinson's disease mortality were significantly elevated following melanoma (SMR = 1.6; 95% CI = 1.1-2.2; SMR = 1.5; 1.2-1.8, respectively). " http://www.ncbi.nlm.nih.gov/pubmed/16103728?ordinalpos=15&itool=EntrezSystem 2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=163 75723 Vitamin B2 inhibits glutamate release from rat cerebrocortical nerve terminals. http://www.ncbi.nlm.nih.gov/pubmed/18695519?ordinalpos=1&itool=EntrezSystem2 .PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Glutamate release facilitators: alpha-lipoic acid http://www.ncbi.nlm.nih.gov/pubmed/16949179?ordinalpos=1&itool=EntrezSystem2 .PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R A&linkpos=2&log$=relatedarticles&logdbfrom=pubmed alpha-tocopherol http://www.ncbi.nlm.nih.gov/pubmed/18037536?ordinalpos=1&itool=EntrezSystem2 .PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R A&linkpos=1&log$=relatedarticles&logdbfrom=pubmed caffeine http://www.ncbi.nlm.nih.gov/pubmed/17372967?ordinalpos=1&itool=EntrezSystem2 .PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R A&linkpos=1&log$=relatedarticles&logdbfrom=pubmed egcg http://www.ncbi.nlm.nih.gov/pubmed/17663453?ordinalpos=1&itool=EntrezSystem2 .PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R A&linkpos=3&log$=relatedarticles&logdbfrom=pubmed aspirin http://www.ncbi.nlm.nih.gov/pubmed/16330128?ordinalpos=8&itool=EntrezSystem2 .PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum ginkgo http://www.ncbi.nlm.nih.gov/pubmed/15910800?ordinalpos=16&itool=EntrezSystem 2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
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