Thread View: alt.support.kidney-failure
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Started by plz.spam.here
Tue, 17 Oct 2006 19:12
BMP-7 and the kidney
Author: plz.spam.here
Date: Tue, 17 Oct 2006 19:12
Date: Tue, 17 Oct 2006 19:12
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2168 bytes
2168 bytes
This is the drug that Ortho Biotech licensed from Curis in late 2002. Unfortunately there is no evidence that Ortho has done anything with BMP-7 since then. Is this because it is puts their current blockbuster drug Procit/Epoetin (http://www.orthobiotech.com/procrit.html) at risk? I really hope not, but who knows? BMP-7 and the Kidney, Introduction: Several recent studies have demonstrated unequivocally that administration of bone morphogenic protein-7 (BMP-7) has a therapeutic effect in various animal models of acute and chronic renal injury (Table 1). However, the underlying mechanisms of BMP-7 action in the kidney remained largely unknown in these initial reports. Here, novel aspects regarding the biology of BMP-7 in the kidney will be discussed. Full study: http://ndt.oxfordjournals.org/cgi/content/full/21/3/568 Ortho licensing BMP-7 from Curis: http://curis.com/product_detail.php?id=3 How can we get Ortho to actually do something with BMP-7, besides sitting on it? P.
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