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Article #91Re: [Cell-biology] Re: Animations of a Possible Cure for Cancer
From: Cathal Garvey
Date: Tue, 15 Nov 2011 10:59
Date: Tue, 15 Nov 2011 10:59
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I seem to recall reading a theoretical article a few years ago that suggested the use of zinc-finger based logic to detect double deletions of critical regulatory genes. The premise was that, even without aneuploidy, many cancer cells will have deleted both alleles of a critical regulator or two along the way, and detecting these deletions would permit pretty selective destruction of cancer cells. The system involved a time-delayed toxin that was inhibited by an antitoxin. The antitoxin was a split protein conjugated to ubiquitins and one of two zinc fingers; if the zinc fingers bound adjecent to one another on an allele, ubiquitin ligase would (theoritically, mind) ligate the two chimeric proteins, and the reconstituted antitoxin would protect the cell from death. Clever, but I've not seen it implemented. I also felt it overcomplicated the first implementation of a fantastic idea; zinc-finger-mediated protein conjugation by ubiquitin ligase. By the way, although mature sperm are haploid, the precursor cells aren't; permanent infertility shouldn't result from a system that attacks aneuploid cells. Mature eggs are diploid as far as I know, only "kicking" the second chromosome set upon fertilisation. I may be under a misapprehension there, though; anyone with more knowledge care to comment? -- www.indiebiotech.com twitter.com/onetruecathal joindiaspora.com/u/cathalgarvey PGP Public Key: http://bit.ly/CathalGKey
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Date: Tue, 15 Nov 2011 10:59:33 +0000
From: Cathal Garvey <cathalgarvey@gmail.com>
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subject: Re: [Cell-biology] Re: Animations of a Possible Cure for Cancer
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