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Dear Dr. Rowell,

I read your interesting reply to Jamie Love's question about  
chromosome 2 fusion in humans and the necessity, or lack of it,  for  
inbreeding to achieve successful mating.  If there is no reproductive  
barrier or reduction in fertility in many cases,  then should it not  
be rather common for a species to have variation in numbers of  
chromosomes, just as there is variation in other heritable  
characteristics that are not strongly selected against?   But this  
does not seem to be the case.

Ron

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Ron Larson

Chair, and GG Brown Professor of Chemical Engineering
Professor of Macromolecular Science and Engineering, Biomedical  
Engineering, and Mechanical Engineering
Dept. of Chem. Engng.
2300 Hayward
Univ. of Michigan
Ann Arbor, MI 48109-2136

rlarson@umich.edu
734 936-0772
FAX 734 763-0459
http://www.engin.umich.edu/dept/cheme/people/larson.html


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<HTML><BODY style=3D"word-wrap: break-word; -khtml-nbsp-mode: space; =
-khtml-line-break: after-white-space; ">Dear Dr. Rowell,<DIV><BR =
class=3D"khtml-block-placeholder"></DIV><DIV>I read your interesting =
reply to Jamie Love's question about chromosome 2 fusion in humans and =
the necessity, or lack of it,=A0 for inbreeding to achieve successful =
mating.=A0 If there is no reproductive barrier or reduction in fertility =
in many cases,=A0 then should it not be rather common for a species to =
have variation in numbers of chromosomes, just as there is variation in =
other heritable characteristics that are not strongly selected against?=A0=
 =A0But this does not seem to be the case.</DIV><DIV><BR =
class=3D"khtml-block-placeholder"></DIV><DIV>Ron<BR><DIV> <P =
style=3D"margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica; =
min-height: 14.0px"><BR></P> <P style=3D"margin: 0.0px 0.0px 0.0px =
0.0px"><FONT face=3D"Helvetica" size=3D"3" style=3D"font: 12.0px =
Helvetica">--<SPAN class=3D"Apple-converted-space">=A0</SPAN></FONT></P> =
<P style=3D"margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica; =
min-height: 14.0px"><BR></P> <P style=3D"margin: 0.0px 0.0px 0.0px =
0.0px"><FONT face=3D"Helvetica" size=3D"3" style=3D"font: 12.0px =
Helvetica">Ron Larson</FONT></P> <P style=3D"margin: 0.0px 0.0px 0.0px =
0.0px; font: 12.0px Helvetica; min-height: 14.0px"><BR></P> <P =
style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT face=3D"Helvetica" =
size=3D"3" style=3D"font: 12.0px Helvetica">Chair, and GG Brown =
Professor of Chemical Engineering</FONT></P> <P style=3D"margin: 0.0px =
0.0px 0.0px 0.0px"><FONT face=3D"Helvetica" size=3D"3" style=3D"font: =
12.0px Helvetica">Professor of Macromolecular Science and Engineering, =
Biomedical Engineering, and Mechanical Engineering</FONT></P> <P =
style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT face=3D"Helvetica" =
size=3D"3" style=3D"font: 12.0px Helvetica">Dept. of Chem. =
Engng.</FONT></P> <P style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT =
face=3D"Helvetica" size=3D"3" style=3D"font: 12.0px Helvetica">2300 =
Hayward</FONT></P> <P style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT =
face=3D"Helvetica" size=3D"3" style=3D"font: 12.0px Helvetica">Univ. of =
Michigan</FONT></P> <P style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT =
face=3D"Helvetica" size=3D"3" style=3D"font: 12.0px Helvetica">Ann =
Arbor, MI 48109-2136</FONT></P> <P style=3D"margin: 0.0px 0.0px 0.0px =
0.0px; font: 12.0px Helvetica; min-height: 14.0px"><BR></P> <P =
style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT face=3D"Helvetica" =
size=3D"3" style=3D"font: 12.0px Helvetica"><A =
href=3D"mailto:rlarson@umich.edu">rlarson@umich.edu</A></FONT></P> <P =
style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT face=3D"Helvetica" =
size=3D"3" style=3D"font: 12.0px Helvetica">734 936-0772</FONT></P> <P =
style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT face=3D"Helvetica" =
size=3D"3" style=3D"font: 12.0px Helvetica">FAX 734 763-0459</FONT></P> =
<P style=3D"margin: 0.0px 0.0px 0.0px 0.0px"><FONT face=3D"Helvetica" =
size=3D"3" style=3D"font: 12.0px Helvetica"><A =
href=3D"http://www.engin.umich.edu/dept/cheme/people/larson.html">http://w=
ww.engin.umich.edu/dept/cheme/people/larson.html</A></FONT></P>  =
</DIV><BR></DIV></BODY></HTML>=

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