Article View: bionet.molbio.evolution
Article #502Re: Quantitating the degree of conservation
From: Don Gilbert
Date: Mon, 01 Feb 2010 01:39
Date: Mon, 01 Feb 2010 01:39
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3354 bytes
THe various protein databases do clustering of genes. You might want to use the number of species or gene copies in a gene cluster as a measure of convervation. E.g. Uniprot's UniRef data set. http://www.uniprot.org/uniref/?query=histone&sort=score (max 5,345 genes at 50% identity) versus http://www.uniprot.org/uniref/?query=obp&sort=score (max 23 genes at 50% id) -- Don On 2010-01-27, Sidney Cambridge <cambridge@ana.uni-heidelberg.de> wrote: > > Dear all, > > I hope my question is not too trivial.... > I am looking for a quantitative measure of the degree of genetic > conservation - basically attaching a high value to highly conserved > genes such as histones and low values to genes that are not very > conserved. Ideally there would be a database for all genes of the > mouse or human genome with a 'conservation' value for each gene. > > Does something like this exist ? > > Thank you very much in advance ! > > Best, > Sidney
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