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Article #6551Re: molecular clocks
From: Marc Roussel
Date: Sun, 08 Sep 1991 18:11
Date: Sun, 08 Sep 1991 18:11
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In article <9109081355.AA14144@evolution.genetics.washington.edu>
joe@GENETICS.WASHINGTON.EDU (Joe Felsenstein) writes:
> The actual formula for probability of fixation of a mutant is (to
>extremely good approximation) given by Kimura's formula:
>
> Prob(fixation) = (1 - exp(-4Nsp))/(1-exp(-4Ns))
>
>with p = 1/(2N) if the mutant is initially present in one copy (s is the
>increase in fitness in the heterozygote carrying the mutant).
I would like to know more about this equation. Is it an empirical
law? If not, what assumptions go into it? Can anyone provide us with a
reference that discusses and/or derives this law with a minimum of
hocus-pocus?
Sincerely,
Marc R. Roussel
mroussel@alchemy.chem.utoronto.ca
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X-Google-Language: ENGLISH,ASCII-7-bit X-Google-Thread: 10a7a9,69df59a5019c44a0 X-Google-Attributes: gid10a7a9,public X-Google-ArrivalTime: 1991-09-08 12:15:00 PST Path: arc1-ca.pugleaf.net!gmdzi!unido!mcsun!uunet!cs.utexas.edu!usc!rpi!news-server.csri.toronto.edu!generic.physics.utoronto.ca!alchemy.chem.utoronto.ca!mroussel From: mroussel@alchemy.chem.utoronto.ca (Marc Roussel) Newsgroups: bionet.molbio.evolution Subject: Re: molecular clocks Message-ID: <1991Sep8.181154.22251@alchemy.chem.utoronto.ca> Date: 8 Sep 91 18:11:54 GMT References: <9109081355.AA14144@evolution.genetics.washington.edu> Distribution: bionet Organization: Department of Chemistry, University of Toronto Lines: 19