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    COMPUTER APLICATIONS IN MOLECULAR BIOLOGY - AN INTRODUCTORY COURSE.

A two day course providing a general practical introduction to some of the uses
of computers in Molecular Biology will be held on the 11th and 12th of July in:

                Room 1, The Old Music School,
                Downing Place,
                Cambridge CB2 3QG.

The provisional program, in outline, is as follows:

Monday  11th July 9.30 - 13.00, 14.15 - 17.30

    - Read sonicated sequences from autoradiographs using a digitiser
    - Use the Staden DB System (the PC based version) to reassemble those
      sequences
    - Use the Staden programs (the PC based version) to variously analyse the
      reassembled sequence
    - Transfer the reassembled sequence to the CSBS VAX (BIO)
    - Search a DNA sequence database stored on BIO for homologous sequences
    - Further investigate interesting homologies using the Staden programs (the
      VAX version).

Tuesday 12th July 9.30 - 13.00, 14.15 - 17.30

    - Compute restriction fragment sizes from an agarose gel photograph
    - Predict possible restriction maps from the computed restriction fragment
      sizes
    - Probe a protein sequence database (stored on the PC) for sequences
      homologous to a given sequence.
    - Further investigate interesting homologies using the Staden programs (the
      PC version).
    - Investigate the potential function of a protein sequence
    - Predict the secondary structure of a protein sequence
    - Predict the secondary structure of an RNA sequence

The teaching laboratory for the course includes seven workstations based on
IBM PCATs. During the course the workstations will be used as stand alone
machines and as terminals to the Cambridge IBM 3084 mainframe (PHX) and BIO.

Some of the IBM PC programs that are used are public domain programs. Course
participants who wish to obtain copies of public domain molecular biology
software for the IBM PC should bring an ample supply of discs.

Temporary IBM 3084 (Phoenix) and VAX projects will be available for course
participants who do not have their own. Application forms for personal
projects will be available.

If required, accomodation can be reserved in Downing College (approximately
15 pounds per night).

The course is free to all who would like to attend. If you would like to come
on the course please contact:

                    David Judge,
                    Computer Laboratory,
                    Corn Exchange Street,
                    Cambridge CB2 3QG

       Telephone: (0223) 334663 (just 4663 on the University exchange)
       Email    : DPJ10@UK.AC.CAM.PHX
                  DPJ10@UK.AC.CAM.BIO

If required, this course will be rerun on the 13th and 14th July.