Article View: bionet.molec-model
Article #151Antigen Presenting cells
From: j_thomas
Date: Mon, 27 Dec 2010 00:24
Date: Mon, 27 Dec 2010 00:24
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Antigen Presenting cells express both MHC molecules,in this case MHC II molecule co stimulator molecule such as CD80.Stimulation of T cells in this case CD4 tcell by the antigen presenting cell involves the interaction of T cell receptor and co receptor molecule with the MHC peptide complex.As well as the interaction between the CD80 and CD28.The interaction of antigen presenting cell with T cell causes signals to pass in both direction.Signalling the antigen presenting cell to express additional co-stimulatary molecules such as CD86 and CD40.At the same time signals to T cell receptor and CD28 induce T cell to express CD40L(CD40 ligand).the interaction between CD40L and CD40 As well the additional stimulation through CD28 mediated by interaction with CD86 resolved in full activation of CD4 T cell. http://www.biosolutions.info/2009/06/tcr-apc-interaction.html
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