Thread View: bionet.organisms.zebrafish
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Started by Chase Williams
Thu, 09 Feb 2012 00:24
Sulforaphane toxicity
Author: Chase Williams
Date: Thu, 09 Feb 2012 00:24
Date: Thu, 09 Feb 2012 00:24
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--20cf3071c7fa909d2204b87d07c2 Content-Type: text/plain; charset=ISO-8859-1 Hello, I am currently conducting a developmental study using zebrafish (EKW). I planned to expose the fish to Sulforaphane from 5hpf until 144hpf. When the fish are exposed to 20uM or 40uM Sulforaphane from 5hpf until 72hpf there is an increased incidence of developmental defects. The defects prove fatal by 96hpf. These defects include a enlarged stomach, underdeveloped heart with only one chamber beating, and an underdeveloped jaw. The DMSO control does not have these defects. Has anyone ever seen this in their studies or heard of this? SFN was supposed to be a chemoprotectant and not cause such fatal defects. Thank you for your help and time. Chase W --20cf3071c7fa909d2204b87d07c2 Content-Type: text/html; charset=ISO-8859-1 Content-Transfer-Encoding: quoted-printable Hello,<br>=A0 I am currently conducting a developmental study=20 using zebrafish (EKW). I planned to expose the fish to Sulforaphane from 5h= pf=20 until 144hpf. When the=20 fish are exposed to 20uM or 40uM Sulforaphane from 5hpf until=20 72hpf there is an increased incidence of developmental defects. The defects= prove fatal by 96hpf. These=20 defects include a enlarged stomach, underdeveloped heart with only one=20 chamber beating, and an underdeveloped jaw. The DMSO control does not have = these defects. Has anyone ever seen=20 this in their studies or heard of this? SFN was supposed to be a chemoprote= ctant and not=20 cause such fatal defects. Thank you for your help and time.<br>=A0 Chase W<= br> --20cf3071c7fa909d2204b87d07c2--
Re: Sulforaphane toxicity
Author: wangd366
Date: Mon, 15 Oct 2012 16:19
Date: Mon, 15 Oct 2012 16:19
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On Wednesday, February 8, 2012 6:24:04 PM UTC-6, Chase Williams wrote: > Hello, > � I am currently conducting a developmental study > using zebrafish (EKW). I planned to expose the fish to Sulforaphane from 5hpf > until 144hpf. When the > fish are exposed to 20uM or 40uM Sulforaphane from 5hpf until > 72hpf there is an increased incidence of developmental defects. The defects prove fatal by 96hpf. These > defects include a enlarged stomach, underdeveloped heart with only one > chamber beating, and an underdeveloped jaw. The DMSO control does not have these defects. Has anyone ever seen > this in their studies or heard of this? SFN was supposed to be a chemoprotectant and not > cause such fatal defects. Thank you for your help and time. > � Chase W Which company made the compound? Do you have the IR spectra for it?
Re: Sulforaphane toxicity
Author: wangd366
Date: Mon, 15 Oct 2012 16:19
Date: Mon, 15 Oct 2012 16:19
14 lines
3343 bytes
3343 bytes
On Wednesday, February 8, 2012 6:24:04 PM UTC-6, Chase Williams wrote: > Hello, > � I am currently conducting a developmental study > using zebrafish (EKW). I planned to expose the fish to Sulforaphane from 5hpf > until 144hpf. When the > fish are exposed to 20uM or 40uM Sulforaphane from 5hpf until > 72hpf there is an increased incidence of developmental defects. The defects prove fatal by 96hpf. These > defects include a enlarged stomach, underdeveloped heart with only one > chamber beating, and an underdeveloped jaw. The DMSO control does not have these defects. Has anyone ever seen > this in their studies or heard of this? SFN was supposed to be a chemoprotectant and not > cause such fatal defects. Thank you for your help and time. > � Chase W Which company made the compound? Do you have the IR spectra for it?
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