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NIH GUIDE - Vol. 26, No. 31 - September 19, 1997

$$INDEX BEGIN *******************************************************

                               NOTICES

$$INDEX N1 **********************************************************

REMINDER - MODIFICATIONS TO THE NIH GUIDE FOR GRANTS AND CONTRACTS
National Institutes of Health
INDEX:  NATIONAL INSTITUTES OF HEALTH

$$INDEX N2 **********************************************************

INCREASE IN TOTAL COSTS FOR PROGRAM PROJECTS
National Institute of Dental Research
INDEX:  DENTAL RESEARCH

$$INDEX N3 **********************************************************

DEMOGRAPHIC RESEARCH ON SEXUAL BEHAVIORS RELATED TO HIV (PAS-97-093)
National Institute of Child Health and Human Development
National Institute of Dental Research
National Institute of Mental Health
INDEX:  CHILD HEALTH, HUMAN DEVELOPMENT; DENTAL RESEARCH; MENTAL
HEALTH

               NOTICES OF AVAILABILITY (RFPs/RFAs/PAs)

$$INDEX R1 01/06/98 *************************************************

QUALITY OF CARE UNDER VARYING FEATURES OF MANAGED CARE ORGANIZATIONS
(RFA HS-98-005)
Agency for Health Care Policy and Research
INDEX:  HEALTH CARE POLICY, RESEARCH

$$INDEX R2 02/18/98 *************************************************

NUTRITION ACADEMIC AWARD (RFA HL-97-011)
National Heart, Lung, and Blood Institute
INDEX:  HEART, LUNG, BLOOD

$$INDEX R3 02/18/98 *************************************************

AIDS INTERNATIONAL TRAINING AND RESEARCH PROGRAM (RFA TW-98-002)
Fogarty International Center
INDEX:  FOGARTY INTERNATIONAL CENTER

$$INDEX P1 **********************************************************

FELINE IMMUNODEFICIENCY VIRUS:  A POTENTIAL MODEL OF AIDS (PA-97-106)
National Institute of Allergy and Infectious Diseases
INDEX:  ALLERGY, INFECTIOUS DISEASES

$$INDEX P2 **********************************************************

PREVENTION OF RECURRENT DISEASE AFTER LIVER TRANSPLANTATION (PA-97-
107)
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute on Alcohol Abuse and Alcoholism
National Institute of Allergy and Infectious Diseases
INDEX:  DIABETES, DIGESTIVE, KIDNEY DISEASES; ALCOHOL ABUSE,
ALCOHOLISM; ALLERGY, INFECTIOUS DISEASES

$$INDEX P3 **********************************************************

STUDIES OF MOLECULAR MECHANISMS OF RENAL INJURY AND RECOVERY (PA-97-
108)
National Institute of Diabetes and Digestive and Kidney Diseases
INDEX:  DIABETES, DIGESTIVE, KIDNEY DISEASES

The NIH GUIDE is available electronically via LISTSERV subscription,
and is also on the NIH gopher (gopher.nih.gov) and the NIH website
(http://www.nih.gov). Alternative access is through the NIH Grant
Line via modem (data line 301/402-2221); contact Dr. John James
at 301/435-2801 for details on the NIH Grant Line.

All competing grant applications submitted to the National Institutes
of Health must be sent to:

DIVISION OF RESEARCH GRANTS
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

ASKNIH is a service of the Division of Extramural Outreach &
Information Resources, Office of Extramural Research, Office of the
Director, NIH.  ASKNIH is the point of contact for obtaining general
information about NIH extramural research & research training
programs, requesting publications, and learning more about obtaining
the NIH GUIDE and other information on the NIH web site.  ASKNIH is
also the contact aid which organizations should request application
kits and forms.

ASKNIH
NATIONAL INSTITUTES OF HEALTH
EMAIL:  ASKNIH@odrockm1.od.nih.gov
FAX:  (301) 480-0525
TELEPHONE:  (301) 435-0714

INQUIRIES ABOUT THE NOTICES, PAs, AND RFAs IN THIS PUBLICATION SHOULD
BE DIRECTED TO THE NIH STAFF MEMBER IDENTIFIED AT THE END OF EACH
ITEM.

THE PHS STRONGLY ENCOURAGES ALL GRANT AND CONTRACT RECIPIENTS TO
PROVIDE A SMOKE-FREE WORKPLACE AND PROMOTE THE NON-USE OF ALL TOBACCO
PRODUCTS.  IN ADDITION, PUBLIC LAW 103-227, THE PRO-CHILDREN ACT OF
1994, PROHIBITS SMOKING IN CERTAIN FACILITIES (OR IN SOME CASES, ANY
PORTION OF A FACILITY) IN WHICH REGULAR OR ROUTINE EDUCATION,
LIBRARY, DAY CARE, HEALTH CARE OR EARLY CHILDHOOD DEVELOPMENT
SERVICES ARE PROVIDED TO CHILDREN.  THIS IS CONSISTENT WITH THE PHS
MISSION TO PROTECT AND ADVANCE THE PHYSICAL AND MENTAL HEALTH OF THE
AMERICAN PEOPLE.

$$INDEX END *********************************************************

                               NOTICES

$$N1 BEGIN **********************************************************

REMINDER - MODIFICATIONS TO THE NIH GUIDE FOR GRANTS AND CONTRACTS

NIH GUIDE, Volume 26, Number 31, September 19, 1997

P.T.

National Institutes of Health

This is a reminder that after September 26, 1997, printed copies of
the NIH Guide for Grants and Contracts will no longer be available.

As described in the June 27 issue of the NIH Guide, the print and
LISTSERV versions of the NIH Guide will be terminated.  The full text
of all Requests for Applications (RFAs), Program Announcements (PAs),
and Notices will be available on the Office of Extramural Research
(OER) Homepage (http:www.nih.gov/grants/oer.htm).

The NIHTOC-L, which contains only the Table of Contents of each weeks
NIH Guide will continue.  To subscribe to the NIHTOC-L, send mail to:
LISTSERV@LIST.NIH.GOV.  The text of the mail should read ONLY:

SUBSCRIBE NIHTOC-L First-name Last-name

e.g., SUBSCRIBE NIHTOC-L John Smith

Anyone currently subscribed to the NIHGDE-L that would like to
receive the Table of Contents list (NIHTOC-L) should subscribe using
the above procedures.

INQUIRIES

Inquiries or comments regarding these procedures may be directed to:

James O'Donnell, Ph.D.
Office of Extramural Programs
National Institutes of Health
6701 Rockledge Drive, Room 6182 - MSC 7910
Bethesda, MD  20892-7910
Telephone:  (301) 435-2768
Email:  odonnelj@od.nih.gov

Myra Brockett
Office of Extramural Programs
National Institutes of Health
6701 Rockledge Drive, Room 6202 - MSC 7910
Bethesda, MD  20892-7910
Telephone:  (301) 435-2694
Email:  mb36t@nih.gov

$$N1 END ************************************************************

$$N2 BEGIN **********************************************************

INCREASE IN TOTAL COSTS FOR PROGRAM PROJECTS

NIH GUIDE, Volume 26, Number 31, September 19, 1997

P.T.

National Institute of Dental Research

The National Institute of Dental Research (NIDR) announces a change
in policy regarding program project grants (P01).  Currently, in
order for a grant to be funded as a P01 it must consist of a minimum
of three research projects, not including cores, and the first year
direct costs may not exceed $500,000.  Grants that include consortium
arrangements may exceed the cap by the amount of the indirect costs
associated with the consortium.

This policy has been in effect for approximately the past five years.
During this time the average first year direct costs for
investigator-initiated individual research grants (R01) has
surpassed, by nearly twenty-five percent, the average costs for a
single project which is part of a P01, thus leading to the situation
whereby research supported by the P01 mechanism may be at a fiscal
disadvantage to that supported by the R01 mechanism.
Also, for fiscal planning purposes, the Institute finds it more
effective to place limits on maximum levels of funding in terms of
total (i.e., direct plus indirect) costs rather than direct costs
alone.

Therefore, effective immediately, the NIDR modifies its policy and
will accept applications for all new (Type 1) and competitively
renewed (Type 2) program projects whose total first year costs (i.e.,
direct plus indirect costs) do not exceed $1.125 million.  This
represents an increase of approximately one-third and brings the
average direct cost of an individual project included in a P01 more
in line with the current average direct costs for an R01 funded by
the NIDR.  While the minimum number of fundable research projects
required for a P01 still remains at three, applicants are strongly
encouraged to plan research supported through P01s to include a
minimum of four fundable projects of high scientific merit.

Potential applicants are reminded of the National Institutes of
Health (NIH) policy (NIH Guide for Grants and Contracts, Volume 25,
Number 14, May 3, 1996) that requires that all applicants receive
prior written approval before submitting a formal investigator-
initiated Type 1 application whose first year direct costs equal or
exceed $500,000.  Prior to submitting a P01 or any other grant
application with first year direct costs above $500,000, applicants
must telephone the extramural scientific program director responsible
for the administration of the scientific subject matter of the
proposed research.  A full listing is available through the NIDR Home
Page (http://www.nidr.nih.gov) and applicants are encouraged to
review the information about extramural scientific program interests
and priorities listed there.  For projects of this size, applicants
should be prepared to provide the following information to NIDR
staff:

o  Overall objectives and goals of the P01 as a whole.
o  Specific aims of each research project as it relates to the
objectives and goals of the P01.
o  Overall and individual project/core budgets including any
consortium costs.
o  Names and institutions/departments of affiliation of key
personnel.

Following review by Institute staff, a written response indicating
whether or not the application falls within the programmatic
interests of the NIDR will be forwarded to the applicant within 15
working days.

INQUIRIES

Additional information regarding these policies can be obtained from
extramural scientific program directors within the Division of
Extramural Research or from Dr. Norman S. Braveman, Assistant
Director for Program Development, Division of Extramural Research,
National Institute of Dental Research (Telephone: (301) 594-2089;
Email: BravemanN@de45.nidr.nih.gov).

$$N2 END ************************************************************

$$N3 BEGIN **********************************************************

DEMOGRAPHIC RESEARCH ON SEXUAL BEHAVIORS RELATED TO HIV

NIH GUIDE, Volume 26, Number 31, September 19, 1997

PA NUMBER:  PAS-97-093

P.T.

National Institute of Child Health and Human Development
National Institute of Dental Research
National Institute of Mental Health

Application Receipt dates: May 1, September 1,  January 1

The following notice is issued for PAS-97-093, which was published in
the NIH Guide, Vol. 26, No. 27, August 15, 1997.

The sponsoring Institutes have committed funds for applications that
are received by the Sept. 1, 1998 deadline.

Applications in response to the PA topic, Demographic Research on
Sexual Behaviors Related to HIV, will continue to be of interest to
the sponsoring institutes and will continue to be considered under
normal funding plans.

INQUIRIES

Inquiries regarding this program announcement may be directed to:

Susan F. Newcomer, Ph.D.
Demographic and Behavioral Science Branch
National Institute for Child Health and Human Development
6100 Executive Boulevard, Room 8B13
Bethesda, MD  20892
Telephone:  (301) 496-1174
FAX:  (301) 496-0962
Email:  NewcomeS@hd01.nichd.nih.gov

Patricia Bryant, Ph.D.
Director, Behavior, Health Promotion and Environment
National Institute of Dental Research
Natcher Building, Room 4AN 18A
45 Center Drive MSC 6402
Bethesda,  MD  20892-6402
Telephone:  (301) 594-2095
FAX:  (301) 480-8318
Email:  BryantP@de45.nidr.nih.gov

Willo Pequegnat, Ph.D.
Office on AIDS
National Institute of Mental Health
5600 Fishers Lane, Room 10-75
Rockville, MD  20857
Telephone:  (301) 443-6100
FAX:  (301) 443-9719
Email:  wpequegn@nih.gov

$$N3 END ************************************************************

               NOTICES OF AVAILABILITY (RFPs/RFAs/PAs)

$$R1 BEGIN HS-98-005 FULL-TEXT **************************************

QUALITY OF CARE UNDER VARYING FEATURES OF MANAGED CARE ORGANIZATIONS

NIH GUIDE, Volume 26, Number 31, September 19, 1997

RFA AVAILABLE:  HS-98-005

P.T.

Agency for Health Care Policy and Research

Letter of Intent Receipt Date:  October 31, 1997
Application Receipt Date:  January 6, 1998

PURPOSE

The Agency for Health Care Policy and Research (AHCPR) invites
applications for cooperative agreements that will assess the
association between features of managed care organizations, health
outcomes, and quality of care for patients with chronic diseases.
These cooperative agreements will be co-sponsored by the American
Association of Health Plans Foundation (AAHPF) under a partnership
agreement with AHCPR.

Studies should focus on one or more conditions meeting the following
criteria:  high prevalence, association of outcomes with quality of
care, ease of severity assessment with inexpensive measures, some
outcomes measurable within a two-year time frame, and adequate
patient numbers across the severity spectrum.  Aggregations of
conditions might be selected for study if the data are adequate and
methodologies are sound, particularly if these conditions apply to
special populations such as children, women, minority populations or
the elderly populations.

AHCPR expects to award up to $1.5 million and AAHPF a comparable
amount in fiscal year 1998 to support the first year of approximately
4 to 7 projects under this RFA. AAHPF and AHCPR will each contribute
half of each project's funding.  Applicants are asked for written
permission to share with AAHPF applications that AHCPR intends to
fund under this RFA, along with a summary of the results of peer
review of those applications.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  AHCPR
encourages applicants to submit grant applications with relevance to
the specific objectives of this initiative.  Potential applicants may
obtain a copy of "Healthy People 2000" (Full Report: Stock No.
017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through
the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325, telephone 202-512-1800.

INQUIRIES

This RFA, which describes the research objectives, application
procedures, review considerations, and award criteria for this
solicitation, may be obtained electronically through the NIH Grant
Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), the
NIH Website (http://www.nih.gov), the AHCPR Website
http://www.ahcpr.gov), and by mail and fax from Global Exchange at
the address listed below.

Global Exchange, Inc.
7910 Woodmont Avenue, Suite 400
Bethesda, MD  20814-3015
Telephone:  (301) 656-3100
FAX:  (301) 652-5264

$$R1 END ************************************************************

$$R2 BEGIN HL-97-011 FULL-TEXT **************************************

NUTRITION ACADEMIC AWARD

NIH GUIDE, Volume 26, Number 31, September 19, 1997

RFA AVAILABLE:  HL-97-011

P.T.

National Heart, Lung, and Blood Institute

Letter of Intent Receipt Date:  December 1, 1997
Application Receipt Date:  February 18, 1998

THIS RFA USES "JUST-IN-TIME" PROCEDURES.  THE RFA INCLUDES DETAILED
MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE
FOLLOWED WHEN PREPARING AN APPLICATION IN RESPONSE TO THIS RFA.

PURPOSE

The primary objective of this initiative is to encourage the
development or enhancement of medical school curricula to increase
opportunities for students, house staff, faculty, and practicing
physicians to learn nutrition principles and clinical practice skills
with an emphasis on preventing cardiovascular diseases (CVD).  A
second objective is to provide training modules for dissemination to
other medical schools as well as other health care professional
schools.  This RFA is part of the Academic Award Program (KO7) of the
National Heart, Lung, and Blood Institute.  It is anticipated that in
fiscal year 1998, support will be available for total costs of
approximately $750,000 and that approximately five grants will be
awarded under this program.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This RFA,
Nutrition Academic Award, is related to the priority areas of
nutrition, heart disease and stroke, obesity, physical activity,
diabetes, chronic disabling conditions, and clinical prevention
services.  Potential applicants may obtain a copy of "Healthy People
2000" (Full Report:  Stock No. 017-001-00474-0 or Summary Report:
Stock No. 017-001-00473-1) through the Superintendent of Documents,
Government Printing Office, Washington, DC 20402-9325 (telephone
202-512-1800).

INQUIRIES

The RFA, which describes the research objectives, application
procedures, review considerations, and award criteria for this
solicitation, may be obtained electronically through the NIH Grant
Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and
the NIH Website (http://www.nih.gov), and by mail and email from the
program contact listed below.

Elaine J. Stone, Ph.D., M.P.H.
Division of Epidemiology and Clinical Applications
National Heart, Lung, Blood Institute
6701 Rockledge Drive, Room 8134, MSC-7936
Bethesda, MD  20892-7936
Telephone:  (301) 435-0382
FAX:  (301) 480-1669
Email:  Stonee@gwgate.nhlbi.nih.gov

$$R2 END ************************************************************

$$R3 BEGIN TW-98-002 FULL-TEXT **************************************

AIDS INTERNATIONAL TRAINING AND RESEARCH PROGRAM

NIH GUIDE, Volume 26, Number 31, September 19, 1997

RFA AVAILABLE:  TW-98-002

P.T.

Fogarty International Center

Letter of Intent Receipt Date:  October 15, 1997
Application Receipt Date:  February 18, 1998

PURPOSE

The Fogarty International Center (FIC), National Institutes of Health
(NIH), invites applications from non-profit private or public U.S.
institutions with interest in working with foreign colleagues to
build global HIV/AIDS research capacity and thereby help to prevent
HIV transmission through development of HIV/AIDS international
training and research programs for foreign health scientists,
clinicians, and allied health workers in collaboration with U.S
scientists in developing countries, including emerging democracies in
Eastern Europe and Latin America.  This announcement is for the third
five-year funding cycle for the AIDS International Training and
Research Program (AITRP).  Both new and competing renewal
applications for this D43 program are welcome.

Prevention, through biomedical or behavioral approaches, is critical
to stop the global spread of HIV/AIDS.  International collaboration
can greatly enhance HIV/AIDS prevention efforts, but to be fully
effective, prevention research in other countries must involve
scientists and health professionals from these countries who are
familiar with the unique local and cultural factors contributing to
the epidemic in their countries, and should also be fully endorsed by
their governments.

A major goal of this program is to train developing country
scientists to address more effectively the AIDS epidemic through
research.  This training program will help to:  (1) establish
critical biomedical and behavioral science expertise in developing
countries affected by HIV/AIDS; (2) facilitate new prevention
research efforts which supplement or complement NIH and other U.S.
AIDS research; (3) establish long-term cooperative relationships
between U.S. and foreign research groups; and (4) support cooperation
between U.S. academic research centers and foreign scientists.
Collaborations supported through this effort will help to facilitate
the conduct of scientifically valid and ethically sound HIV/AIDS
prevention, technology testing and research.

Funds will be awarded to provide training in the various scientific
disciplines required to conduct HIV/AIDS research in accordance with
the stated objectives for the program.  Applicants are strongly
encouraged to relate training to ongoing prevention research efforts
in developing countries supported by NIH and other organizations.

In October, 1996, the FIC convened a panel of scientists to conduct a
comprehensive review of the AITRP program.  The present announcement
reflects most of the recommendations of the panel as described in
their report.  In addition, the recommendations from the NIH AIDS
Research Program Evaluation Task Force, contained in the "Levine"
Report, contributed to this Request for Applications (RFA).  For
example, the need to develop a coordinated and comprehensive
Prevention Science Agenda that includes and combines biomedical,
behavioral, and social interventions was underscored.  Applicants are
encouraged to request copies of both of these documents from the FIC.
This RFA also reflects guidance of other NIH components, including
the Office of AIDS Research (OAR), the National Institute of Allergy
and Infectious Diseases (NIAID), the National Institute of Child
Health and Human Development (NICHD), the National Cancer Institute
(NCI), the National Institute of Dental Research (NIDR), the National
Institute on Drug Abuse (NIDA), and the National Institute of Mental
Health (NIMH).  The FY 1999 NIH Plan for HIV-Related Research,
available from the FIC, describes the range of prevention research
encompassed within the "Levine" report and emphasizes the importance
of international cooperation and multidisciplinary prevention
research to combat the global spread of HIV/AIDS.

The FIC AITRP program review noted that the program has become an
important component of global research on AIDS and related diseases
and that, by integrating research and research training, and by its
inherent flexibility, the AITRP is adding significant value to the
human resource capability for research and disease prevention in
developing countries. This RFA refocuses AITRP from an emphasis on
epidemiology to prevention research involving multiple disciplines,
which will require a broader research perspective.  Accordingly, the
overall focus of prevention research training in the new FIC AITRP
should be multidisciplinary.

Based upon the review of the AIDS International Training and Research
Programs (AITRP), the FIC has adopted the following mission and goal
statement for the next funding cycle of the AITRP.

"The mission of the AITRP is to train international health
professionals in research on prevention of HIV infection."

The interpretation of this mission statement, in the context of the
overall AITRP review, is broad, encompassing not only prevention of
HIV transmission and infection, but also prevention of progression of
HIV infection to AIDS, which may reduce the likelihood of HIV
transmission by infected individuals.  AITRP, by strengthening
research and public health capacity in developing countries, will
help to:
o  prevent HIV-uninfected persons from becoming HIV-infected;
o  prevent HIV-infected persons from transmitting HIV to uninfected
persons (including prevention of mother-to-child transmission); and
o  prevent HIV disease progression in infected individuals which, as
noted above, may also help to further reduce the spread of HIV.

Five specific goals are to:

o  Encourage development of genuine collaboration and equal
partnerships between investigators in different countries;
o  Assist developing countries achieve independent capacity to
conduct their own
research and training;
o  Encourage independent local research on HIV prevention;
o  Assist NIH institutes to conduct their research missions related
to HIV; and
o  Stimulate multidisciplinary cooperation.

Applicants are strongly encouraged to propose multidisciplinary
training in one or more areas in each of the two broad fields of
biomedical and behavioral research, in addition to a core component
of data management and analysis.  Biomedical research areas may
include basic science, clinical science, epidemiology (as a subset of
prevention research), behavioral change, and vaccine research.
Behavioral research areas may include the social sciences, behavioral
change, economics, policy issues, etc.  Data management and analysis
includes protocol development, biostatistics, data collection
procedures, and quality control.

The research focus of the AITRP will remain HIV/AIDS.  This includes
specific HIV-related co-factors, namely opportunistic infections,
STDs, TB, and HIV-associated reproductive health issues but only
insofar as they specifically relate to HIV/AIDS.

This program will continue to emphasize support for trainees from,
and training activities in, the developing countries of Africa, Latin
America and the Caribbean, Asia and the Pacific region.  The program
will also accommodate trainees from, and training activities in,
countries of Central and Eastern Europe and the former Soviet Union.
However, AITRP is not expected to necessarily be active in all
countries with significant HIV incidence or prevalence.  Rather, the
demonstrated capacity and/or potential to achieve sustained research
and training efforts within a country will be the priority.  In this
regard, research capacity is built in large part by participation in
research and thus AITRP programs are strongly encouraged to link
training with NIH-supported and other research programs in common
countries in such a manner that training and research mutually
reinforce each other.  The emphasis in AITRP will be depth, not
breadth; that is, programs which focus on a relatively few sites or
countries would have a greater impact than those which dilute their
resources across many countries.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This Request
for Applications, "AIDS International Training and Research Program
(AITRP)," is related to the priority of HIV infections.  Potential
applicants may obtain a copy of "Healthy People 2000" (Full Report:
Stock No. 017-001-00474-0 Summary Report: Stock No. 017-001-0473-1)
through the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202-512-1800).

INQUIRIES

The RFA, which describes the research objectives, application
procedures, review considerations, and award criteria for this
solicitation, may be obtained electronically through the NIH Grant
Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and
the NIH Website (http://www.nih.gov), and by mail and email from the
program contact listed below.

Kenneth Bridbord, M.D.
Division of International Training and Research
Fogarty International Center
31 Center Drive, Room B2C32 - MSC 2220
Bethesda, MD  20892-2220
Telephone:  (301) 496-2516
FAX:  (301) 402-2056
Email:  bridbord@nih.gov

$$R3 END ************************************************************

$$P1 BEGIN PA-97-106 FULL-TEXT **************************************

FELINE IMMUNODEFICIENCY VIRUS:  A POTENTIAL MODEL OF AIDS

NIH GUIDE, Volume 26, Number 31, September 19, 1997

PA AVAILABLE:  PA-97-106

P.T.

National Institute of Allergy and Infectious Diseases

PURPOSE

The National Institute of Allergy and Infectious Diseases (NIAID)
gives special consideration for funding to scientifically meritorious
applications in response to Program Announcements (PAs).  These PAs
identify areas of ongoing research emphasis for the NIAID.  The
Division of AIDS, NIAID, solicits applications on the molecular
biology, immunology, and host factors involved in feline
immunodeficiency virus (FIV) infection of cats.  The overall goal of
these studies is to advance the understanding of the virus/host
infection process in this model and to determine the potential use
and/or validate the application of the FIV/cat model for testing
potential therapeutics, topical microbicides, and novel
mucosal-targeted vaccine designs against HIV.  Applicants proposing
studies focusing solely on FIV pathogenesis are encouraged to apply
under PA-96-072 "Mechanisms of AIDS Pathogenesis".  Traditional
research project grants (R01), small grants (R03), and First
Independent Research Support and Transition (FIRST) awards (R29) may
be submitted in response to this program announcement.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
Feline Immunodeficiency Virus:  A Potential Model of AIDS, is related
to the priority area of HIV infection.  Potential applicants may
obtain a copy of "Healthy People 2000" (Full Report:  Stock No.
017-001-00474-0 or Summary Report:  Stock No. 017-001-00473-1)
through the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202-512-1800).

INQUIRIES

The PA, which describes the research objectives, application
procedures, review considerations, and award criteria for this
solicitation, may be obtained electronically through the NIH Grant
Line (data line 301-402-2221), the NIH GOPHER (gopher.nih.gov), and
the NIH Website (http://www.nih.gov), and by mail or e-mail from the
program officer, listed below.

Roger H. Miller, Ph.D.
Division of AIDS
National Institute of Allergy and Infectious Diseases
6003 Executive Boulevard, Room 2C36A
Bethesda, MD  20892-7620
Telephone:  (301) 496-8197
FAX:  (301) 402-3211
Email:  rm42i@nih.gov

$$P1 END ************************************************************

$$P2 BEGIN PA-97-107 FULL-TEXT **************************************

PREVENTION OF RECURRENT DISEASE AFTER LIVER TRANSPLANTATION

NIH GUIDE, Volume 26, Number 31, September 19, 1997

PA AVAILABLE:  PA-97-107

P.T.

National Institute of Diabetes and Digestive and Kidney Diseases
National Institute on Alcohol Abuse and Alcoholism
National Institute of Allergy and Infectious Diseases

Letter of Intent Receipt Date:  December 9, 1997
Application Receipt Date:  January 9, 1998

PURPOSE

To encourage experienced and new investigators to submit small grants
(R03s) to plan multicenter clinical trials or to submit research
project grants (R01s) to conduct full-scale multicenter clinical
trials on methods for preventing the recurrence of disease after
liver transplantation.  Of major relevance are studies on preventing
the recurrence of alcoholic liver disease, and preventing the
recurrence of hepatitis B and C virus infection after liver
transplantation.  Specific interventions should be compared.  It is
of interest to learn about the natural history of these diseases in
patients undergoing standard therapy.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This program
announcement (PA), Prevention of Recurrent Disease after Liver
Transplantation, is related to the priority area of chronic disabling
conditions.  Potential applicants may obtain a copy of "Healthy
People 2000 (Full Report:  Stock No. 017-001-00474-0 or Summary
Report:  Stock No. 017-001-00473-1) through the Superintendent of
Documents, Government Printing Office, Washington, DC 20402-9325
(telephone 202-512-1800).

INQUIRIES

The PA, which describes the research objectives, application
procedures, review considerations, and award criteria for this
solicitation, may be obtained electronically through the NIH Grant
Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), the
NIH Website (http://www.nih.gov), and by mail or email from the
program official contact listed below.

Tommie Sue Tralka
Division of Digestive Diseases & Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
45 CENTER DR MSC 6600
BETHESDA, MD 20892-6600
Telephone:  (301) 594-8879
FAX:  (301) 480-8300
Email:  tralkat@ep.niddk.nih.gov

$$P2 END ************************************************************

$$P3 BEGIN PA-97-108 FULL-TEXT **************************************

STUDIES OF MOLECULAR MECHANISMS OF RENAL INJURY AND RECOVERY

NIH GUIDE, Volume 26, Number 31, September 19, 1997

PA AVAILABLE:  PA-97-108

P.T.

National Institute of Diabetes and Digestive and Kidney Diseases

PURPOSE

The Division of Kidney, Urologic and Hematologic Diseases (DKUHD) of
the National Institute of Diabetes and Digestive and kidney Diseases
announce a continuing interest in receiving research project
applications on the above subject.

The need for this initiative was recognized, in part, as a result of
the recommendations emanating from the conference held at the NIH in
May 1996, organized and sponsored by the DKUHD, titled "Acute Renal
Failure in the 21st Century." A report from the meeting summarized
recommendations from the participants, which included a set of
published recommendations for patient management and outcomes
assessment (AJKD, Vol. 29, # 5, 793-799, 1997).  Also advocated was
the development and establishment of a multi-center database as one
mechanism to facilitate cooperative multi-center studies.  It was
further recommended that research initiatives be undertaken to
enhance the transfer of new body of knowledge derived from basic
studies and laboratory investigation (including cellular and
molecular aspects of tissue injury, changes in cell differentiation,
cell repair mechanisms, cell death and organ recovery) to the
clinical management of ARF.  With a more complete understanding of
these fundamental aspects of the pathophysiological response by the
kidney to ARF, it is anticipated that new therapies and potentially
novel uses of replacement therapies may emerge.  Additional insight
in this field will likely emerge from another conference convened by
the American Society of Nephrology, with support from the NIDDK
("Mechanisms of Tissue Injury and Repair") that will be convened
November 1997.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas. Potential
applicants may obtain a copy of "Healthy People 2000 (Full Report:
Stock No. 017-001-00474-0 or Summary Report: Stock No.
017-001-00473-1) through the Superintendent of Documents, Government
Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800).

INQUIRIES

The PA, which describes the research objectives, application
procedures, review considerations, and award criteria for this
solicitation, may be obtained electronically through the NIH Grant
Line (data line 301/402-2221), the NIH GOPHER (gopher.nih.gov), and
the NIH Website (http://www.nih.gov), and by mail and email from the
program contact listed below.

M. James Scherbenske, Ph.D.
Division of Kidney, Urologic and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 6AS.19E
45 CENTER DR MSC 6600
BETHESDA, MD 20892-6600
Telephone:  (301) 594-7719
FAX:  (301) 480-3510
Email:  scherbensk@extra.niddk.nih.gov

$$P3 END ************************************************************