Thread View: bionet.structural-nmr
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Started by Ling-Hong Hung
Tue, 16 Jul 2002 20:35
New NMR secondary structure assignment software
Author: Ling-Hong Hung
Date: Tue, 16 Jul 2002 20:35
Date: Tue, 16 Jul 2002 20:35
15 lines
1845 bytes
1845 bytes
We'd like to announce some new software for assigning secondary structure which is now available from our webserver. PsiCSI: Secondary structure from sequence and chemical shifts PsiCSI uses neural networks to translate chemical shifts to secondary structure information and combine it with sequence based prediction algorithms (PsiPred). For a rigorously jack-knifed set of 92 proteins, PsiCSI made 36% fewer errors than CSI, achieving a sustained 3-state accuracy of 89%. In addition, because of the sequence based component, the method remains effective with sparse and incomplete chemical shift data. A webserver is available at <http://protinfo.compbio.washington.edu/> Hong Hung (lhhung at compbio.washington.edu)
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