🚀 go-pugleaf

<<Disclaimer: Verify this information before applying it to your situation.>>

Mary Anne Cripe's question was:
" does that mean I could be getting damage without knowing it because I have no
 obvious reaction?"

        Based on our studies  a  typical (biopsy proven flat mucosa, proved
 immune reactions to gluten) gluten intolerant patient does not react
 immediately with clinical symptoms for a gluten challenge (J Pediatr
 Gastroenterol Nutr 1989, 9:176-180)..     However, ingestion of GRAMS OF GLUTEN
 causes several changes in the intestine.

1. There is an accumulation of inflammatory cells
2. One cell type -so called mast cells- releases factors which factors in
 long-term     damage the villi and  they also release a factor which
3. Increases the permeability -leakiness- of the intestine, which is a
 temporarily change after a single ingestion but may be permanent after repeat
 dietary mistakes.

I hope it answers your question,

Karoly Horvath, M.D., Ph.D.
Baltimore

----------------------------------------------------------------------
Date: Fri, 20 Feb 1998 09:59:04 -0500
      From: Mary Anne Cripe <mcripe@WESTGA.EDU>
      Subject: Question re gluten reaction my gastroenterologist could not
 answer

      <<Disclaimer: Verify this information before applying it to your
 situation.>>
      I have a question that I hope someone can answer; it may need to be a
      doctor. My gastroenterologist could not answer this; he said I knew more
      about celiac disease than he did.
      I'll try to make this as brief as possible. I was diagnosed the end of
      September because of osteoporosis. I was also anemic and hypothyroid
      because of the malabsorption. However, I wasn't even aware that I was
      sick; my internist just happened to ask if I had ever had a bone density
      test when I went for a physical. I didn't feel that bad, and yet the
 biopsy
      showed no villi, the small intestine crusted over, and nodules. I knew I
      was lactose intolerant, but I continued to eat ice cream so, of course,
 did
      have some distention. And, now that I know the symtoms I did have other
      symptoms, too, (bloating, hip pain, persistent skin and scalp rashes for
      years, leg cramps--but no pain or diarrhea) I have off and on had problems
      keeping weight on, but I did not have any drastic weight loss.
      I mistakenly got some gluten last week--I ate a half a bowl of soup before
      I realized it had wheat flour in it. The rest of the day I tried to be
      real aware of any reaction--and I had none. So, my question is--if I don't
      have any reaction, does that mean I'm not getting any damage, OR does that
      mean I could be getting damage without knowing it because I have no
 obvious
      reaction?
      This group has been so helpful to me, and I enjoy reading the posts and
      summaries.

      Mary Anne

      Mary Anne Cripe
      State University of West Georgia
      Carrollton, Georgia 30118

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