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                                     COLLOQUIUM

                University at Albany - State University of New York

                            Computer Science Department

                3D Imaging with the Transmission Electron Microscope

                 and the Concept of a Complex Structural Data Base

                                 Dr. Joachim Frank

                  Wadsworth Center of Laboratories and Research,
                      New York State Department of Health and
                   Department of Biomedical Sciences, SUNY Albany

               TODAY:  Wednesday, December 9, 1992 at 2:30pm in LI-98

                                      ABSTRACT

                 Three-dimensional imaging techniques by electron  microscopy
            and  computer  image  processing along with the new generation of
            light microscopes promise to  revolutionize  cell  biology.   The
            image processing group at the Wadsworth Center has had a pioneer-
            ing role in developing electron tomography and related methods of
            3D  imaging  of  asymmetric  biological  objects.  Some groups in
            other  laboratories  are  developing  instruments  for  automatic
            tomography.  A problem of increasing concern is how to archive 3D
            images in a general, sharable form, and how to relate  data  sets
            to  each  other  that represent different states or aspects of an
            object  (part/whole  relationship,  different  conformations   or
            shapes, different experimental signals, etc.)