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Nerve and Muscle Excitation, 3rd Ed 
By Douglas Junge 

Soft Cover, Sinauer Press, 1992, 263 Pages 

CONTENTS 

PREFACE 

IMPORTANT QUANTITIES USED IN THIS BOOK 

1 ELECTRICAL RECORDINGS FROM NEURONS AND SINGLE MUSCLE FIBERS 
The Compound Action Potential The Frog Nerve Variation of Conduction
Velocity with Fiber Diameter The Node of Ranvier The Sucrose Gap
Intracellular
Recording Optical Recording of Membrane Potentials Problems References

2 THE MEMBRANE ANALOGUE 
Electrical Properties of Neuron Cell Bodies Current-Voltage Relation
Cable Properties of Axons and Muscle Fibers Cable Theory Propagation
of the Action Potential
Effects of Membrane Infolding Soma-Axon Coupling in Real Neurons
Problems References

3 IONIC PROPERTIES OF RESTING AND ACTIVE MEMBRANES 
Asymmetric Distribution of Ions across the Membrane The Nernst-Planck
Equation for a Single Cation The Goldman-Hodgkin-Katz Equation
Calculation of
Current-Voltage Curve Measurement of PNa/PK Ratio Al kali-Cation
Selectivity Eisenman Theory Parallel-Conductance Model of the Membrane
Eyring Rate Theory
Calcium Effects Problems References 

4 METABOLIC PUMPS AND MEMBRANE POTENTIALS 
Electrogenic Nature of the Sodium-Potassium Pump Posttetanic
Hyperpolarization Electrogenic Pumps and Blocking Agents Stimulation
of Electrogenic Pumps
Voltage Dependence of the Pump Currents Pump Reactions Model of the
Unstimulated Pump: The Membrane at Steady State Model of the
Stimulated Pump: The
Membrane Not at Steady State Density of Sodium Pumping Sites Hydrogen
Ion Pumping Problems References

5 VOLTAGE CLAMPING 
Measurement of Membrane Currents Separation of Sodium and Potassium
Currents Instantaneous Current-Voltage Relation Activation and
Inactivation Internally
Perfused Axons Effects of Calcium on Membrane Currents Problems
References

6 THE HODGKIN-HUXLEY MODEL AND OTHER THEORIES OF EXCITATION 
Prediction of Voltage-Clamp Currents Theoretical Potassium and Sodium
Conductances Prediction of Propagated Action Potential Threshold and
Other Membrane
Phenomena Confirmation of Predicted Ion Movements Modification of the
Model for the Node of Ranvier Alternative Models Problems References

7 FURTHER STUDIES OF THE SODIUM AND POTASSIUM CURRENTS 
Independent Effects of Potential on Sodium and Potassium Currents
Different Ion Selectivities of Early and Late Currents Pharmacological
Specificities of the Early
and Late Currents Density of TTX Binding Sites in the Membrane Removal
or Slowing of Sodium Inactivation Blockage of Currents by Local
Anesthetics Gates and
Filters Gating Current Transient Outward Current Cat+-Activated
Potassium Current Problems References

8 CALCIUM CONDUCTANCES AND ACTION POTENTIALS Divalent Spikes and
Bi-ionic Potentials Calcium Spikes Mixed SodiumCalcium Spikes Calcium
Current in Squid Sodium Channels Intracellular Calcium Indicators
Significance of Calcium Spikes Regulation of Intracellular Calcium
Concentration Developmental
Changes in Calcium, Sodium, and Potassium Channels Problems References

9 REPETITIVE FIRING 
Examples of Rhythmicity Effects of Low-Calcium Solutions
Refractoriness and Two-Factor Theories of Firing Frequency Repetitive
Discharge in a Model Axon
Modeling the Molluscan Neuron Other Axons Fre quency Adaptation The
Burst Pattern of Discharge Problems References

10 SYNAPTIC TRANSMISSION 
Nerve-Nerve Synapses Nerve-Muscle Synapses The Postsynaptic Potential
Miniature Postsynaptic Potentials Probabilistic Model of Transmitter
Release Identification
of Quanta with Vesicles Calcium and Transmitter Release The Squid
Synapse Synaptic Facilitation Parallel-Conductance Model of the
Postsynaptic Membrane Ionic
Basis of the Postsynaptic Potential Receptors and Channels Models of
Synaptic Transmission Light-Activated Synaptic Agonists Problems
References

11 SINGLE-CHANNEL CURRENTS IN EXCITABLE MEMBRANES Noise Analysis Motor
Endplates Artificial Membranes Single-Channel Recording Potassium
Channels Sodium Channels Acetylcholine Receptor Channels Other Ion
Channels Problems References

12 THEORIES OF SINGLE-CHANNEL BEHAVIOR Statistics of Channel Opening
and Closing Endplate Noise Analysis Single-Channel Currents in
Artificial
Membranes Delayed Rectifier Potas sium Channels Sodium Channels
Acetylcholine Receptor Channels Blockage by Local Anesthetics
Modifications of Theories from'
SingleChannel Observations Problems References 

13 STRUCTURAL BASIS OF CHANNEL FUNCTION 2 Density of Channels Channel
Size Gating Sites Location of Blocking Sites Inferences about Channel
Structure Acetylcholine Receptors Genotype of the Acetylcholine
Receptor Sodium Channels Primary Structure of Sodium Channels
Potassium Channels
Site-Directed Mutagenesis Other Channel Structures Problems References

14 NEW DIRECTIONS 
Neuromodulation Ion Channel Diversity Diversity in Research References