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		Colloquium on Computational Biology

         http://www.umiacs.umd.edu/users/liberato/ccb/

                     Whole Genome Phylogeny

                            Ming Li
                     University of Waterloo

               Wednesday, October 20, 1999, 4 p.m.
                          AVW 2168

                           Abstract

We are witnessing a revolution in molecular biology and medicine: 
complete genomes for dozens of species are already available; 
genomes for many other species, including the H. sapiens, will be 
completed very soon.

Analyzing such information becomes the most interesting question in 
bioinformatics research. In this talk, we will present an elegant theory and 
a program for measuring the distance between two genomes. 
Using these, we are able to construct evolutionary trees (consistent with 
known trees), for the first time, from complete genomes.

I will survey major known phylogenetic methods, including our own algorithms, 
and compare them with the new paradigm. Our new algorithm does not need 
multiple sequence alignment, does not suffer from the problem of getting
different trees for different genes, and uses the complete information of a 
genome. I will also present strong experimental support for the new theory.


The Colloquium on Computational Biology is a series of talks in Computational 
Biology and Computational Neurosciences. CCB is sponsored by UMIACS.