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<BASE HREF=3D"http://www.dml.georgetown.edu/~davidsol/len.html">

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<head><TITLE>* Genetics Guide *</TITLE>
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<A HREF=3D"http://www.dml.georgetown.edu/www/imagemap/~davidsol/titlec-old.=
gif.map" >
<img src=3D"titlec-old.gif" ISMAP alt=3D"Len Davidson: Genetics Librarian, =
Georgetown Univ Medical Center" align=3Dtexttop  border=3D0>
</A>




<p><br>
As a librarian in the <a href=3D"http://www.dml.georgetown.edu/www/newtop">=

Georgetown Univ Medical Library</a>, I help researchers take advantage of  =
WWW genetics resources (eg OMIM, Entrez, and BLAST) and this page gives a  =
basic overview of these sites.  In addition, I teach classes in the Interne=
t, HTML, and computer applications (eg <A HREF=3D"http://www.microsoft.com/=
MSOffice/products.map?141,222">Word</A>, <A HREF=3D"http://wp.novell.com/bu=
saptoc.htm">WordPerfect</A>, and Excel).    Our Computer Lab offers  over <=
A HREF=3D"http://www.dml.georgetown.edu//library/calendars/birccal.html">20=
 different classes</A>  each month. <P>

For information about human <B>genetic disorders</B> (eg cystic fibrosis or=
 neurofibromatosis) the place to start is <A HREF=3D"http://www3.ncbi.nlm.n=
ih.gov/Omim/"><B>OMIM</B></A>.   This is the Online  Mendelian Inheritance =
in Man database, which is produced by Johns Hopkins.  Each OMIM record cons=
ists of a genetic disorder.  And each record has an informational part (eg =
symptoms or clinical manifestations) and a bibliographic  part (eg recent a=
rticles that cite this disorder).  Most of the references cited in OMIM are=
 not available in general libraries.  They will only be carried in a medica=
l or science library.  <BR>
[One trick to searching OMIM: eliminate possessives and common words.  For =
example, to locate "Zellweger's Syndrome", just type in "Zellweger".]<p>

If you can't find it in OMIM, the disorder may be in  <A HREF=3D"http://www=
2.ncbi.nlm.nih.gov/medline/query_form.html">genetics subsection of MEDLINE<=
/A>.   Complete MEDLINE, the bibliographic database produced by NLM, is gen=
erally only available through academic libraries or hospitals.  <P>

If  your interest is <B>Clinical Genetics</B> the place to start is the <A =
HREF=3D"http://www.kumc.edu/GEC/prof/geneprof.html">U of Kansas Genetics Pa=
ge</A>.    Debra Collins,   a professional Genetics Counselor,  has  compil=
ed a comprehensive list genetic courses,  <A HREF=3D"http://www.faseb.org/g=
enetics/mainmenu.html">genetics societies</A>,  and  <A HREF=3D"http://www.=
kumc.edu/GEC/support/supgroup.html">support groups</A> for different geneti=
c disorders.<p>

Particularly if you are Clinical Genetics Professional, you want to find ou=
t about and register with HELIX, a directory of Medical Genetic Labs.    It=
 is a centrialized directory of Medical Labs that test for different geneti=
c disorders.    Please note: this service is NOT available to the general p=
ublic.   To register for this (FREE) service, please contact:  =

<dl><dd>Maxine Covington--  [Voice:  206-528-2689  or FAX: 206-528-2687] =

<dd>Children's Hospital and Medical Center
<dd>PO Box 5371, Mail Stop CH-94
<dd>Seattle   WA   98105
</dl><p>

A similar site that is open to the public is <A HREF=3D"http://biochemgen.u=
csd.edu/wbgtests.htm">UCSD Genetics Test list</A>.  HELIX has also generate=
d another exciting project, <A HREF=3D"http://www.hslib.washington.edu/genl=
ine ">GenLine</A>.  Although its only in the development stage,  it's  desi=
gned to assist clinicians in applying new developments in genetic testing t=
o the diagnosis and counseling of families with inherited disorders. Entrie=
s are to be expert-authored and peer-reviewed.<P>

<!--The <A HREF=3D"http://www.faseb.org/genetics/abgc/abgcmenu.htm"  Americ=
an Board of Genetic  Counseling</A   page gives  info on their certificatio=
n examination program, list of training programs, and a  membership directo=
ry.--> <p>  =


<B>Teachers</B> looking for  sites for  genetics educational resources  can=
 go to <A HREF=3D"http://www.kumc.edu/instruction/medicine/genetics/homepag=
e.html">U of Kansas Ed Page</a>, =

 <A HREF=3D"http://www.gene.com:80/ae/">Access Excellence</a>, <A HREF=3D"h=
ttp://www.lbl.gov/Education/ELSI/ELSI.html">ELSI Project</A> <FONT SIZE=3D-=
1>(middle school)</FONT>, <A HREF=3D"http://darwin.cshl.org/index.html">Col=
d Sping Harbor</A> , <A HREF=3D"http://www.stg.brown.edu/MendelWeb/">Mendel=
 Web</A>, <A HREF=3D"http://copernicus.bbn.com/genscope/home.html">GenScope=
</A>, or <A HREF=3D"http://shgc-www.stanford.edu/Education.html">Stanford</=
A>. <!--Access Excellence is a national educational program sponsored by Ge=
nentech Inc. for  high school biology teachers.-->  <!--The first two,  hav=
e pointers to sites  covering genetic counseling, ethics & genetic research=
, careers in molecular biology.  The Stanford page is about the an educatio=
nal project out of their Genome Center-->  And each of these have lists of =
links to other educational pages.  But my favorite? The <A HREF=3D"http://w=
ww.ems.psu.edu/~fraser/BadScience.html">BAD Science page</A>.<p>
<!--http://shgc-www.stanford.edu/Education.html-->
 =

Looking for genetics books?  I have compiled a short <A HREF=3D"#books">bib=
liography</A>  for  our library. [Yes, an old fashioned reading list!!]<P>

If you're a <B>Molecular Biologist</B>, you're probably familiar with <a hr=
ef=3D"http://www.gcg.com/index.html">GCG</a> (Genetics Computer Group).   T=
heir home page tells about the company and their services.   GCG software i=
s used to acess GenBank, the database of DNA & protein sequences.  Using GC=
G, researchers can search for sequences, produce restriction maps, fold RNA=
 molecules, and design PCR primers.  Here at the Medical Library, I am the =
resident expert on GCG, and I have produced an <a href=3D"http://www.dml.ge=
orgetown.edu/library/gcg.html">introductory GCG guide</a> to help beginners=
 master the VMS version of the software.

<P>To use GenBank via the Web, please go to the National Library of Medicin=
e home page and use <A HREF=3D"http://www.ncbi.nlm.nih.gov/">Entrez or BLAS=
T</A>.  <B>Entrez</B> allows to search Genbank via keywords (eg author, acc=
ession number, gene name). <B>BLAST</B>  allows you to search Genbank via a=
 nucleotide or protein  sequence (eg  GCTGTGCAA..... or KNHHDK.....).   For=
 papers contrasting different search algorithms, <A HREF=3D"#algorithms">se=
e below</A>.  For  lists of sites please go to: =

<UL>
<LI><A HREF=3D"http://www.public.iastate.edu/~pedro/rt_1.html">Pedro's  Res=
earch Tools</A>   <FONT SIZE=3D-1>(eg yeast sequences,  macromolecule cryst=
allization Databases)</FONT>,
<li><A HREF=3D"http://www.gen.cam.ac.uk/Library/geneticswww.html">Genetics =
Library (U of Cambridge)</A>
<li><A HREF=3D"http://diogenes.baylor.edu/WWWproviders/molecular_genetics/h=
ome-orig.html">Baylor Molecular Genetics</A>
<li><A HREF=3D"http://www.ornl.gov/TechResources/Human_Genome/home.html">Hu=
man Genome newsletter</A>  <FONT SIZE=3D-1> (Has lists of conferences, and =
grant info)</FONT> =

</UL>
Scientists with an intrest in <B>phylogeny</B> and <B>biodiversity</B> can =
go to the <A HREF=3D"http://phylogeny.arizona.edu/tree/phylogeny.html">Tree=
 of Life</A>.  It contains identification keys, figures, phylogenetic
trees, and other taxonomic information for a group of organisms.<P>

To locate studies about <B>radiation</B> and <B>genetic mutations</B> pleas=
e go to <A HREF=3D"http://www.rerf.or.jp/">Radiation Effects Research Found=
ation</A>.<P>

 =


<br> <A NAME=3D"note">
Note:  My technical training is in Computer Science, not genetics, so unfor=
tunately I am NOT qualified to answer questions involving genetics issues. =
 Also,  I can <BLINK>not</BLINK> accept requests from the public for librar=
y materials or searches.   This page should help you start your Web search =
for genetics information.  </A>Please  try this comprehensive <A HREF=3D"ht=
tp://www.dml.georgetown.edu/library/genetics.html">genetics guide</A>.  Any=
 feedback, how this page is helpful or incomplete, would be <B>gratefully a=
ppreciated</B>. =

<p>   =


Thanks, Len =

<br><dl><dt><dd>Len Davidson<dd>Medical Library, Georgetown University,<dd>=
 3900 Reservoir Rd, Washington DC  20007  =


<dd>Voice:  (202) 687-1537     Fax: (202) 687-1703.
<dd><b><A HREF=3D"mailto:davidsol@medlib.georgetown.edu">davidsol@medlib.ge=
orgetown.edu</a></b>
</dl>

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<IMG  SRC=3D"http://www.dml.georgetown.edu/~davidsol/rainbow.gif"  alt=3D"_=
______________________________________________________"  ALIGN=3DTOP>
<p>

<H3>Introductory Guides</H3>
<ol>
<li><A HREF=3D"http://http://nitro.biosci.arizona.edu/zbook/book.html">Quat=
itative Genetics Textbook</A> <FONT SIZE=3D-1>(U of Arizona)</FONT>
<li><A HREF=3D"http://www.cshl.org/books/g_a/chapter25/">Cold Spring Harbor=
 introduction:</A> Molecular biology
<li><A HREF=3D"http://falcon.cc.ukans.edu/~jbrown/pcr.html">PCR</A> Introdu=
ction <FONT SIZE=3D-1>(U of Kansas)</FONT>
<li><A HREF=3D"http://www.gdb.org/Dan/DOE/intro.html">DOE</A> Primer on Mol=
ecular Biology =

<li><A HREF=3D"http://www.kumc.edu/instruction/medicine/genetics/prof/ashgh=
and.html">Clinical Genetics</A> Computer Resources <FONT SIZE=3D-1>(U of Ka=
nsas)</FONT> =

<li><a href=3D"http://www.dml.georgetown.edu/library/genetics.html">Molecul=
ar Biology</a>  Sources on the Web <FONT SIZE=3D-1>(By L Davidson - broader=
 focus than this page)</FONT>

<li><a href=3D"http://www.dml.georgetown.edu/library/gcg.html">GCG: Genetic=
s Computer Group Software</a> <FONT SIZE=3D-1>(By L Davidson)</FONT>
<li><a href=3D"http://www.dml.georgetown.edu/library/gcg-dwl.html">GCG down=
loading/uploading</a><FONT SIZE=3D-1> (From IBM Kermit only)</FONT> =


<li><a href=3D"http://www.dml.georgetown.edu/library/emacs.html">EMACS: a U=
NIX editor</a><A NAME=3D"algorithms">
<li><A HREF=3D"http://geoff.biop.ox.ac.uk/papers/rev93_1/rev93_1.html">Sear=
ching Protein Sequences</A> <FONT SIZE=3D-1>(U of Oxford) </FONT>
<li><A HREF=3D"http://twod.med.harvard.edu/seqanal/index.html">Sequence Sea=
rching: BLAST vs FASTA</A> <FONT SIZE=3D-1>(Harvard) </FONT> =

</ol><BR><BR>

<A NAME=3D"books">
<IMG  SRC=3D"http://www.dml.georgetown.edu/~davidsol/rainbow.gif"    alt=3D=
"_______________________________________________________"  ALIGN=3DTOP>
<H3>Bibliography on Genetic Disorders</H3>

<OL></A>
<li><B>Birth Defects Encyclopedia</B> by Mary Buyse MD,  Blackwell Scientif=
ic Publications, 1990.
<li><B>Diagnostic Recognition of Genetic Disease</B> by Willian Nyhan and N=
adia Sakati, Lea & Febiger, 1987.
<li><B>ABC of clinical genetics</B> by Helen M. Kingston, BMJ Publishing Gr=
oup, 1994.
<li><B>Methods for genetic risk assessment</B>  edited by David J. Brusick,=
 =

Lewis Publishers, 1994.
<li><B>Human heredity: principles and issues</B> by Michael Cummings, West =
Pub,  1994.
<li><B>Handbook of Genetic Skin Disorders</B> by Fred Novice et al,  WB Sau=
nders, 1994.
</OL>
<br><br>

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Last Changed:  April 3, 1996
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