Article View: sci.bio
Article #4523Re: What does allele mean ?
From: greg.dressler Greg Dressler
Date: Sat, 03 Dec 1994 14:33
Date: Sat, 03 Dec 1994 14:33
29 lines
2405 bytes
2405 bytes
I think you are getting to technical in a field that is more abstract. The position of genetic loci are not measured in base pairs, the are positioned on a genetic map of each chromosome. Thus, each gene is positioned only with respect to other genes. The distances between genes are expressed in centi-Morgans (after the great geneticist Thomas Morgan) and these distances are not actual physical lengths, rather they represent recombination frequencies between genes. The position of genes are not necessarily important for their function. There is no obvious reason why genes are where they are. Alleles are on the same genetic locus by definition. An allele is really the same gene! It is a slight variation of a gene product. For example, at a single hair color locus the genes for blonde or brown hair are allelic. You have one or the other, but not both. The actual proteins that these genes encode are probably slight variations of each other. Crossing over has nothing to do with alleles. Just think of it this way. If genes did not have alleles, we would all be identical, as in twins. Do you understand? Humans have all the same genes at the same loci, that is what makes us human. However, we have many different combinations of alleles at most loci, thus we are all a bit different. Alleles generally are regulated the same way, by the same promoter sequences. The differences between two alleles are really quite small and may only represent a single base-pair change that may change one amino acid. Good luck with your studies. Greg Dressler Howard Hughes Med. Inst. Univ. of Michigan, Ann Arbor
Technical Details
Message-ID:
<greg.dressler-0312941733380001@229.32.med.umich.edu>Path:
arc1-ca.pugleaf.net!bga.com!news.sprintlink.net!hookup!europa.eng.gtefsd.com!newsxfer.itd.umich.edu!news.itd.umich.edu!229.32.med.umich.edu!userReferences:
<3bjm7l$ptt@woodstock.socs.uts.EDU.AU>Show Full Headers
Complete Article Headers
X-Google-Language: ENGLISH,ASCII-7-bit X-Google-Thread: 107c0a,20c8c3f75b181bad X-Google-Attributes: gid107c0a,public X-Google-Thread: 1119a6,20c8c3f75b181bad X-Google-Attributes: gid1119a6,public X-Google-ArrivalTime: 1994-12-03 13:35:09 PST Path: arc1-ca.pugleaf.net!bga.com!news.sprintlink.net!hookup!europa.eng.gtefsd.com!newsxfer.itd.umich.edu!news.itd.umich.edu!229.32.med.umich.edu!user From: greg.dressler (Greg Dressler) Newsgroups: sci.bio,bionet.general Subject: Re: What does allele mean ? Date: Sat, 03 Dec 1994 17:33:38 +0300 Organization: Howard Hughes Institute Lines: 29 Message-ID: <greg.dressler-0312941733380001@229.32.med.umich.edu> References: <3bjm7l$ptt@woodstock.socs.uts.EDU.AU> NNTP-Posting-Host: 229.32.med.umich.edu