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Started by patrick carnahan phillips
Tue, 29 Sep 1992 14:26
Sequential Bonferroni: OK to use?
Author: patrick carnahan phillips
Date: Tue, 29 Sep 1992 14:26
Date: Tue, 29 Sep 1992 14:26
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I was wondering what the statistical community thinks of the Sequential Bonferroni test proposed by Holm (1979 Scand J Statist 6:65-70). This adjustment attempts to control Type 1 errors much in the same way that the standard Bonferroni method, except that it is much more lenient (powerful). It works like this: In an ordinary Bonferroni adjustment, the comparisonwise error rate (alpha[ind]) is controlled by dividing the experimentwise error by the number of comparisons to be made (alpha[exp]/n). It is known that this tends to conservatively set the true experimentwise error <= alpha[exp]. In the sequential Bonferroni method, much the same adjustment is made, but instead of testing all comparisons at the alpha[exp]/n level, you only divide alpha[exp] by the number of tests (or comparisons) remaining. As soon as you reach a non-significant result, however, you stop testing. For example, if the p-values for five different tests were 0.008 0.01 0.012 0.02 0.04 setting alpha[exp] = 0.05 only the first two tests would be significant by the standard Bonferroni criteria, but all tests would be significant by the sequential Bonferroni method. What do statisticians think of this method? Predictably, it has not made it into any text books that I have seen. It is becoming popular among population biologists because of a paper by Rice (1989 Evolution 43:223-225). Is it OK to use? Patrick Phillips University of Texas at Arlington phil@decster.uta.edu
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