Thread View: sci.med.immunology
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Started by L.Altenb erg,delete SPAM
Tue, 29 Jun 1999 00:00
S. aureus vaccine & multi-septicemias
Author: L.Altenb erg,delete SPAM
Date: Tue, 29 Jun 1999 00:00
Date: Tue, 29 Jun 1999 00:00
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A vaccine against Staphylococcus aureus is reported by McKenney et al. (Science 294: 1523, May 28, 1999) to be near fruition. I wonder how a vaccine can possibly work in light of the following. Many patients get S. aureus septicemia from central venous access ports. The experience of infection ought to be far more immunogenic that exposure to selected antigens. Both a humoral and a cutaneous response are found in cases of line sepsis. Yet S. aureus septicemia does not render a patient immune to further line septicemias. Multiple infections are possible. If previous infection with S. aureus in not sufficient to develop protective immunity, how can there be any hope that a vaccine can provide such protection? -- ====================================================================== Lee Altenberg, Ph.D. Fax: (808) 875-0348 E-mail: SPaltenberAM@santafe.edu (delete SPAM) Web: http://pueo.mhpcc.edu/~altenber/ ======================================================================
Re: S. aureus vaccine & multi-septicemias
Author: Thomas Jefferson
Date: Tue, 29 Jun 1999 00:00
Date: Tue, 29 Jun 1999 00:00
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L.Altenb erg,delete SPAM wrote: > > A vaccine against Staphylococcus aureus is reported by McKenney et al. > (Science 294: 1523, May 28, 1999) to be near fruition. > > I wonder how a vaccine can possibly work in light of the following. Many > patients get S. aureus septicemia from central venous access ports. The > experience of infection ought to be far more immunogenic that exposure to > selected antigens. Both a humoral and a cutaneous response are found in > cases of line sepsis. Yet S. aureus septicemia does not render a patient > immune to further line septicemias. Multiple infections are possible. If > previous infection with S. aureus in not sufficient to develop protective > immunity, how can there be any hope that a vaccine can provide such > protection? > -- > ====================================================================== > Lee Altenberg, Ph.D. > > Fax: (808) 875-0348 > E-mail: SPaltenberAM@santafe.edu (delete SPAM) > Web: http://pueo.mhpcc.edu/~altenber/ > ====================================================================== Lee, from what i understand the vaccine was directed at virulence-related proteins that get expressed once the bug is in the body. I can't answer why individuals who become septicimic can suffer bouts of this bug disease either. lastly, from what i remmeber from the abs. the work is in mice right now. but good question! markH
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