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J Rheumatol 1998 Oct;25(10):1986-90 

Effect of gamma-hydroxybutyrate on pain, fatigue,
and the alpha sleep anomaly in patients with
fibromyalgia. Preliminary report.

Scharf MB, Hauck M, Stover R, McDannold M, Berkowitz D

Center for Research in Sleep Disorders, Cincinnati, Ohio, USA. 

OBJECTIVE: To evaluate the effects of using a gamma-hydroxybutyrate
(GHB)
administered in divided doses at night in 11 patients previously
diagnosed
with fibromyalgia (FM). METHODS: Subjects completed daily diaries
assessing
their pain and fatigue levels and slept in the sleep laboratory before
and
one month after initiating GHB treatment. Polysomnographic recordings
were
evaluated for sleep stages, sleep efficiency and the presence of the
alpha
anomaly in non-REM sleep. RESULTS: There was a significant improvement
in
both fatigue and pain, with an increase in slow wave sleep and a
decrease
in the severity of the alpha anomaly. CONCLUSION: Further controlled
studies are needed to characterize the clinical improvement and the
polysomnographic changes we observed.