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Article #68Re: I1 recetor agonists
From: Ian Musgrave
Date: Mon, 26 Aug 1996 00:00
Date: Mon, 26 Aug 1996 00:00
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1876 bytes
G'Day All
bernd rupp <rupp@pharm.uni-duesseldorf.de> writes:
>From: bernd rupp <rupp@pharm.uni-duesseldorf.de>
>Subject: I1 recetor agonists
>Date: 23 Aug 1996 21:50:18 -0700
>Dear all,
>who knows the pKa value of rilmenidine, azepexole and ganfacin?
>Thanks for help
For I1 receptors? In what tissue? I don't think anyone has a Ka for these
substances, I can give you Ki's though.
Ki (nM)
Drug Adrenal Medulla Bovine RVLM
azepexole ND 1140
guanafacine ND 2500
rilmenidine 84 6
ND=not determined
A big problem in this field is that rarely do two different investigators use
the same panel of imidaoline/ oxazoline /guanadinium compounds.
Hope this helps, cheers Ian
---------------------------------------------
Ian Musgrave Ph.D, Prince Henry's Institute of Medical Research
PO Box 5152, Clayton 3168, Australia.
Phone +61 3 550 4286 FAX +61 3 550 6125
Lab: Ian.Musgrave@med.monash.edu.au <http://www.mmcc.monash.edu.au/~ian-mu/>
Private: Reynella@werple.mira.net.au <http://werple.mira.net.au/~reynella/>
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X-Google-Language: ENGLISH,ASCII-7-bit X-Google-Thread: 105e35,fd8fcfd38f7450d9 X-Google-Attributes: gid105e35,public X-Google-Thread: f4552,fd8fcfd38f7450d9 X-Google-Attributes: gidf4552,public X-Google-Thread: 1045ed,fd8fcfd38f7450d9 X-Google-Attributes: gid1045ed,public From: IAN-MU@med.monash.edu.au (Ian Musgrave) Subject: Re: I1 recetor agonists Date: 1996/08/26 Message-ID: <IAN-MU.609.322146CA@med.monash.edu.au> X-Deja-AN: 176499067 distribution: world references: <4usp6l$rlj@selene.rz.uni-duesseldorf.de> organization: PHIMR at Monash Medical Center newsgroups: sci.med.pharmacy,bionet.biology.cardiovascular,bionet.neuroscience