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Int Clin Psychopharmacol 1997 Jul;12 Suppl 3:S35-8 

The efficacy and acceptability of amineptine
versus fluoxetine in major depression.

Dalery J, Rochat C, Peyron E, Bernard G

Hopital Neurologique, Lyon, France. 

The temporal dimension, particularly anticipation, appears to be a
very
important component in the understanding of depressed patients. In a
90-day
multicentre study, the efficacy and acceptability of amineptine and
fluoxetine were compared in 169 patients with major depression.
Comparison
of the two antidepressants was based on double-blind methods, after
random
allocation of the treatments between two parallel groups. The two
drugs did
not differ over the whole course of the study, but the improvement in
scores on day 4 was globally more marked in the amineptine than the
fluoxetine group. Intragroup analysis showed that amineptine was
significantly superior to fluoxetine on the retardation pole of the
mood,
anxiety, retardation, danger scale. The positive effect of amineptine
on
anticipation may enable the depressed patient to make plans for the
future.
Anticipation may be a key dimension to be more precisely explored in
specific psychopharmacological protocols with antidepressants. 

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