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CLINICAL STAFF FELLOWSHIP IN
 BRAIN IMAGING IN AGING AND ALZHEIMER DISEASE
LABORATORY OF NEUROSCIENCES,  NATIONAL INSTITUTE ON AGING

Clinical Staff Fellowship available, immediately to July 1997, at the
Laboratory of Neurosciences (LNS) at the National Institute on Aging,
for Physicians with residency training in Radiology, Nuclear Medicine,
Neurology, Psychiatry, Geriatrics or Internal Medicine, to participate
in research on brain function and structure in aging, Alzheimer
disease, and neurodevelopmental disorders.  The Fellowship provides an
opportunity  to carry out original research and to develop a
bibliography to be competitive in a clinical research setting.

Positron emission tomography (PET) and functional magnetic resonance
imaging (fMRI) are used to examine brain glucose utilization and/or
blood flow in subjects who are at rest or performing cognitive tasks
involving memory or attention, or who are subjected to passive visual
or auditory stimuli of varying intensity and difficulty (stress
tests).  In vivo brain signal transduction involving phospholipids is
examined with new positron-labeled fatty acids, whereas labeled
ligands help to quantify receptor abnormalities.  Activation studies
are combined with drugs to identify mechanisms and sites of central
drug action, and basis of efficacy in Alzheimer disease.  MR
spectroscopy is used to quantify brain metabolites, whereas structural
MRI is used to determine volumes of individual brain structures and
white matter hyperintensities in aging and disease, and to correct
functional measurements for atrophy and partial voluming.  Goals are
to understand brain mechanisms of aging and disease, and to provide an
early diagnosis and identify subjects at risk for Alzheimer disease.  

Coming to the LNS would be very rewarding to a physician wishing to
establish a research career on brain aging and disease.  Applicants
require an MD and U.S. medical license (ECFMG certification if foreign
physician).  Starting salary commensurate with training and
experience.  For further information, contact M. B. Schapiro, M.D.
Chief, Brain Aging and Dementia Section, Laboratory of Neurosciences,
National Institute on Aging, National Institutes of Health, 9000
Rockville Pike, Building 10, Room 6C414, Bethesda, MD  20892.  Tel:
(301) 496-4754, FAX 301 402 0595.