case studies for animal research?

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2 total messages Started by The Oracle Tue, 02 Apr 1991 02:19

#187

Author: The Oracle
Date: Tue, 02 Apr 1991 02:19

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I am doing research about using laboratory animals for scientific research.  I 
need case studies desperately, as the paper is due on the 11th? or 14th? of
April, and I do not have any case studies.  I have exhausted all the resource
areas I know, and have not come up with any case studies.  Any help in this area
would be greatly appreciated.  As I have stated, this is due very soon, and I
need this information very soon.  I am on both sides of the issue- meaning that
I recognize the need for using animals for research, but feel that too many 
animals are being used, as there is too much unnecessary killing going on with
duplication of studies that have already been proven time and time again (or
disproven)
I thank you all for your immediate responses and all you help in advance.
	Alex.
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Re: case studies for animal research?

#188

Author: V P Demikhov
Date: Wed, 03 Apr 1991 05:28

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In article <11869.27f795ed@zeus.unomaha.edu> conslt01@zeus.unomaha.edu (The Oracle) writes:
>I am doing research about using laboratory animals for scientific research. 
>I need case studies desperately, as the paper is due <in about two weeks>...
>I recognize the need for using animals for research, but feel that too many 
>animals are being used ... with duplication of studies that have already 
>been proven time and time again (or disproven) ...

Case Study #1

Take, for example, the enormous literature demonstrating the memory for
conditioned taste aversion in the rat depends critically on the insular
neocortex. Numerous experiments by investigators over the past 30 years
demontrate that destruction of the insular cortex abolishes preexisting
memory for taste aversion.  However, no previous investigator took care
to avoid damage to the middle cerebral artery in the course of excising
the insular cortex.  When you carefully avoid any damage to this artery
while removing the insular neocortex the memory remains unharmed.  This
means that although the experiment has been repeated many times by many
investigators -- they were all wrong -- the effect came from infarcting
over half of the brain; not from the destruction of the insular cortex.

The simple lesson then is that you cannot just trust the literature ---
even if the literature has grown to a substantial volume of experiments
by a large number of investigators over the years.  In the words of one
of one of our greatest leaders (on detent): "TRUST ... BUT VERIFY!!!"

VPD

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