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Article #8639

Re: Cell Division Number

#8639
From: Aldor
Date: Mon, 10 Feb 1997 00:00
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AgAcademy wrote:
> 
> Aldor wrote:
> 
> > I wonder if anyone has tried increasing the length of units on the
> > telomeres of mice.  Would they grow bigger, live longer, or neither?
> 
> How difficult will it be to turn on the telemerase gene in somatice
> cells?  Has this been done in vitro?

Just changing the number of units in a fertilized mouse egg cell might
be interesting.  I think mice or some other rodents only have a few
chromosomes which would make it easier still.  One might have to extract
the chromosomes and add longer telomeres through splicing or the use of
telomerase, then readd to the cell.  One could check the embryo for
telomere number.  How are the telomeres' unit numbers added in gamete or
fertilized egg cells?  Is it as seperate germ cells or in the newly
fertilized cell?  Are the exact numbers of units to be added well
regulated and if so how?  Or are germ cells like skin cells in that they
will not decrease telomere length?
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From: Aldor <kopek@loren.com.ar>
Subject: Re: Cell Division Number
Date: 1997/02/10
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