🚀 go-pugleaf

On May 12, 9:41 am, hackedyetag...@japan.com (ayaz) wrote:
> Human Molecular Genetics
>
> Activation of =A6=C2-catenin signaling by Rspo1 controls differentiation of
> the mammalian ovary
>
> Anne-Amandine Chassot1,2, Fariba Ranc1,2, Elodie P. Gregoire1,2,
> Hermien L. Roepers-Gajadien3,4, Makoto M. Taketo5, Giovanna Camerino6,
> Dirk G. de Rooij3, Andreas Schedl1,2 and Marie-Christine
> Chaboissier1,2,*
>
> 1 INSERM, U636, F-06108 Nice, France 2 Laboratoire de G=A8=A6n=A8=A6tique du=
>
> D=A8=A6veloppement Normal et Pathologique, Universit=A8=A6 de Nice-Sophia
> Antipolis, F-06108 Nice, France 3 Department of Endocrinology, Utrecht
> University, 3584 CH Utrecht, The Netherlands 4 Center for Reproductive
> Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands
> 5 Department of Pharmacology, Graduate School of Medicine, Kyoto
> University Yoshida-Kono=A8=A6-cho, Sakyo, Kyoto 606-8501, Japan 6
> Dipartimento di Patologia Umana ed Ereditaria, Sezione di Biologia
> Generale e Genetica Medica, Universita di Pavia, Via Forlanini 14,
> 27100 Pavia, Italy
>
> * To whom correspondence should be addressed. Tel: +33 492076451; Fax:
> +33 492076402; Email: chabo...@unice.fr
>
> Received November 14, 2007; Accepted January 16, 2008
>
> ABSTRACT
> The sex of an individual is determined by the fate of the gonad. While
> the expression of Sry and Sox9 is sufficient to induce male
> development, we here show that female differentiation requires
> activation of the canonical =A6=C2-catenin signaling pathway. =A6=C2-catenin=
>
> activation is controlled by Rspo1 in XX gonads and Rspo1 knockout mice
> show masculinized gonads. Molecular analyses demonstrate an absence of
> female-specific activation of Wnt4 and as a consequence XY-like
> vascularization and steroidogenesis. Moreover, germ cells of XX
> knockout embryos show changes in cellular adhesions and a failure to
> enter XX specific meiosis. Sex cords develop around birth, when Sox9
> becomes strongly activated. Thus, a balance between Sox9 and =A6=C2-catenin
> activation determines the fate of the gonad, with Rspo1 acting as a
> crucial regulator of canonical =A6=C2-catenin signaling required for female
> development.

i would very much appreciate it if the google admins could delete
posts that are not directed from this legitimate path. i am noting an
alteration of my posting history due to my name being hijacked by a
vandal. thnx.