🚀 go-pugleaf

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Postdoctoral position as posted on Postdoc Jobs website:

http://www.PostdocJobs.com
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A NIH-funded postdoctoral research positions is available in the
Department of Pharmacology at the University of Vermont College of
Medicine, Burlington, Vermont.

The research is in the field of molecular and cellular neuroscience,
focusing on the cell biology of voltage gated ion channel modulation.

Our goal is to understand the cellular and molecular mechanisms of
receptor mediated ion channel modulation. We focus on a relatively
unique form of ion channel regulation, that mediated by channel
tyrosine phosphorylation. Our model system is the voltage gated
delayed rectifyer potassium channel Kv1.2. Tyrosine phosphorylation of
the Kv1.2 protein causes strong suppression of the channel's ionic
current. We have shown that the small G-protein RhoA has central role
in receptor mediated channel suppression. Our recent data suggests a
role for tyrosine phosphorylation dependent interaction of Kv1.2 with
components of the actin cytoskeleton. Our current efforts are directed
at testing this hypothesis. In particular, we are actively exploring
the role of RhoA and other actin cytoskeleton modulating proteins that
bind to Kv1.2, as well as signaling by cadherin, integrin, growth
factor and muscarinic receptors in channel modulation.

To accomplish this we use a combination of techniques, including
western analysis, immunoprecipitation, subcellular fractionation, in
vitro protein binding assays, phosphorylation site mapping,
fluorescence microscopy (including in vivo detection of GFP tagged
proteins), mammalian tissue culture, electrophysiology (whole cell and
single channel patch clamp), cDNA plasmid construction and site
directed mutagenesis.


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For more information, please visit PostdocJobs website

http://www.PostdocJobs.com

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