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Article #378PostdocJobs.com => Postdoc in molecular biology/immunology
From: Postdoc.com
Date: Tue, 11 Apr 2006 19:41
Date: Tue, 11 Apr 2006 19:41
24 lines
3682 bytes
3682 bytes
POSTDOCTORAL POSITIONS immediately available to study epigenetic gene regulation during lymphocyte development using a combination of genetic and molecular methods. The projects are based on published data (Nature 2002; Immunity 2003; Nature Review Immunology 2004), and on exciting recent technical progress. Specifically, we have developed a novel and general strategy to generate mice carrying conditional point mutation; improved chromatin immunoprecipitation and in vivo footprinting assays for detecting transient protein-DNA interactions and for quantifying subtle changes in chromatin structure, respectively; and finally we are setting up 3C and FISH assays to study high order chromatin organization. Using these tools, we are addressing "big questions" in gene regulation. Our preliminary data indicate that chromatin remodeling complexes have novel functions beyond classical ATPase-dependent remodeling; calcium signaling directly impinges on a chromatin remodeling via direct binding of calmodulin to a chromatin remodeler; epigenetic gene silencing is signaled by specific histone modifications. The new postdoc can participate in these or other projects including defining genome-wide changes in chromatin landscape during lineage commitment and differentiation, and using shRNA library to identify genes essential for epigenetic gene regulation. Expertise in gene regulation is preferred. Immunology background is a plus but dispensable. For more information visit http://www.PostdocJobs.com
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X-Google-Thread: f5161,31f4be861a6e5ffc,start X-Google-Thread: f8886,31f4be861a6e5ffc,start X-Google-Thread: fdd1a,31f4be861a6e5ffc,start X-Google-Attributes: gidf5161,gidf8886,gidfdd1a,public X-Google-Language: ENGLISH,ASCII-7-bit Path: arc1-ca.pugleaf.net!g2news1.google.com!news3.google.com!news4.google.com!newshub.sdsu.edu!logbridge.uoregon.edu!news.indiana.edu!e56g2000cwe.googlegroups.com!not-for-mail From: "Postdoc.com" <postdocjobs@hotmail.com> Newsgroups: sci.research.postdoc,sci.research.careers,bionet.jobs.offered Subject: PostdocJobs.com => Postdoc in molecular biology/immunology Date: 11 Apr 2006 12:41:50 -0700 Organization: http://groups.google.com Lines: 25 Approved: BIOSCI Approval Key <biosci-approval-key@net.bio.net> Message-ID: <mailman.573.1144792212.16885.biojobs@net.bio.net> NNTP-Posting-Host: oat.bio.indiana.edu Mime-Version: 1.0 Content-Type: text/plain; charset="iso-8859-1" X-Trace: rainier.uits.indiana.edu 1144792247 3360 129.79.225.149 (11 Apr 2006 21:50:47 GMT) X-Complaints-To: news-admin@indiana.edu NNTP-Posting-Date: Tue, 11 Apr 2006 21:50:47 +0000 (UTC) To: bionet-jobs-offered@moderators.isc.org User-Agent: G2/0.2 X-HTTP-UserAgent: Mozilla/4.0 (compatible; MSIE 6.0; Windows NT 5.1; SV1; .NET CLR 1.1.4322),gzip(gfe),gzip(gfe) Complaints-To: groups-abuse@google.com Injection-Info: e56g2000cwe.googlegroups.com; posting-host=207.179.72.254; posting-account=-scWWwwAAABsnA17UPr9G_vA-OXM1Q81 X-Greylisting: NO DELAY (Relay+Sender autoqualified); processed by UCSD_GL-v2.1 on mailbox4.ucsd.edu; Tue, 11 April 2006 12:41:56 -0700 (PDT) X-Spamscanner: mailbox4.ucsd.edu (v1.6 Aug 4 2005 15:27:38, -1.7/5.0 3.0.4) X-MailScanner: PASSED (v1.2.8 13915 k3BJftEP031442 mailbox4.ucsd.edu) X-Mailman-Approved-At: Tue, 11 Apr 2006 16:49:35 -0500 X-BeenThere: biojobs@net.bio.net X-Mailman-Version: 2.1.4 Precedence: list X-Auth: PGPMoose V1.1 PGP bionet.jobs.offered iQCVAwUBRDwklKCIqsWvyF5FAQHcKQP/ZjRIlyy1LkPkypgpwafqquY79kY5HR47 7A8cZwgh3oNh8u3Dfe9A5HPFvGkPR7LUhDcJm1q5NnaljtMB6mk6JAppx0NBToWp 5X6wf9OS+TmFrYrTxYitT7jAnWLQi4dfZwN1yTO/N2GLSvEXI+HVJL9yO3CdYncI u3eByZaDQcw= =YAkq