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Article #588statistics for testing spatial heterogeneity of mtDNA haplotype frequencies
From: BIO252
Date: Tue, 10 Jan 1989 20:47
Date: Tue, 10 Jan 1989 20:47
24 lines
1560 bytes
1560 bytes
In a paper by DeSalle et al. (1987; Genetics 116:215-223) a method is proposed to assess heterogeneity between populations using mtDNA haplotypes using arsin, square-root transformed frequency of a given haplotype in the following statistic: V = 4 x summation ni *((ai - mean a) squared) where ni = the number of individuals in the ith sample, ai = the number of individuals in the ith pop. with the haplotype of interest, mean a = sum ni x ai/N, N = total number of individuals in all pop. and r = the number of populationns. Under the null hypothesis of no geographical heterogeneity, V is distributed as a Chi-Square with r-1 degrees of freedom. The significance of Fst values are tested with the V statistic. In examples with two haplotypes, alternate haplotypes give similar V values. But where several haplotypes occur, it appears that V values calculated for any one of them may underestimate or over estimate between population heterogeneity. Any suggestions on how to alter this statistic to give an average of all alleles?
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Path: arc1-ca.pugleaf.net!utzoo!attcan!uunet!yale!yalevm!BIO252 From: BIO252@YaleVM.YCC.Yale.Edu Newsgroups: sci.research,sci.bio,sci.math.stat,bionet.molbio.evolution Subject: statistics for testing spatial heterogeneity of mtDNA haplotype frequencies Message-ID: <189@YaleVM.YCC.Yale.Edu> Date: 10 Jan 89 20:47:46 GMT Reply-To: BIO252@YaleVM.YCC.Yale.Edu Organization: Yale University, New Haven, CT, USA Lines: 24 Disclaimer: Author bears full responsibility for contents of this article