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Article #10

PROPOSED: Consortium to obtain isotopically labelled compounds

#10
From: Paul H Axelsen
Date: Thu, 01 Sep 1994 15:25
88 lines
4222 bytes

          -----------------------------------------------
                 ISOTOPICALLY LABELLED COMPOUNDS
          ------------------------------------------------


I am seeking to identify other investigators interested in 

              _____________________________________

               A CONSORTIUM-type GRANT APPLICATION 
              _____________________________________


to order the custom synthesis of "L" amino acids with a SINGLE 13-C label in 
the peptide backbone (carbonyl) group (see list of expensive or unavailable
compounds below).

At this point, NO COMMITMENT to join such an application is being requested,
or to join in the purchase of anything.  I am merely trying to identify
investigators with A POTENTIAL INTEREST so that I may target further
information and future correspondence.

If you are interested in the results of this posting, or in receiving
further correspondence in regards to this matter, PLEASE RESPOND BY EMAIL.

...........................................................................

If you have related or "slightly" different interests  . . . 

(e.g. labelled 'aib', D-amino acids, or an 15-N label in the peptide group), 

please also respond and indicate your specific interest.  If you wish these 
compounds to be prepared as Fmoc or t-Boc derivatives, please indicate this 
and your preference (Fmoc or t-Boc) as well.



        ________________________________________________________

        At this time, Cambridge Isotope Labs catalogue indicates 
         the following with respect to 13-C(1) L amino acids:
        ________________________________________________________


Price between $100-700/gm:

1.  PHE
2.  GLY
3.  VAL
4.  LEU
5.  SER
6.  ALA

between $1000-1600/gm:

7.  TYR
8.  ILE
9.  THR
10.  PRO

not yet priced or unavailable:

11. ARG
12. TRP
13. ASP
14. GLU
15. GLN
16. LYS
17. CYS
18. MET
19. ASN
20. HIS


--

------------------------------------------------------------------------------
--------------------- axe@pharm.med.upenn.edu --------------------------------
                                                                              
Paul H. Axelsen MD            ....   ....  .   .  .   .    215-898-9238 (ofc) 
Department of Pharmacology    .   .  .     ..  .  ..  .    215-898-9766 (lab) 
University of Pennsylvania    ....   ...   . . .  . . .    215-573-2236 (fax) 
3620 Hamilton Walk            .      .     .  ..  .  ..    610-293-1659 (home)
Philadelphia, PA 19104-6084   .      ....  .   .  .   .                       

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From: axelsen@axe1.med.upenn.edu (Paul H Axelsen)
Newsgroups: sci.techniques.spectroscopy,sci.techniques.mag-resonance,bionet.biophysics,bionet.structural-nmr,sci.chem.labware,fj.sci.chem,fj.sci.misc,sci.bio,sci.chem,sci.physics,sci.research
Subject: PROPOSED: Consortium to obtain isotopically labelled compounds
Date: 1 Sep 1994 15:25:32 GMT
Organization: University of Pennsylvania
Lines: 88
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Summary: Interest in 13-C labelled amino acids sought
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