🚀 go-pugleaf

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Voigt Global Distribution

http://www.voigtglobal.com

Your international supplier of chemicals, nutritional supplements,
pro-hormones, food additives, herbs, plant extracts / essential oils,
and laboratory equipment.


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Cyclo Diol XS� (19 Nor-4-Androstene-3,17-Diol plus 
4-Androstene-3,17-Diol): This is the most advanced prohormone delivery 
system on the market. Both of the most potent prohormones available 
today are bound on the inside of a beta-cyclodextrin molecule 
(a doughnut shaped glucose molecule). This allows the hormone 
combination to pass through the liver with a much higher degree of 
protection against destruction. In addition, much of the hormone is 
absorbed directly through the oral mucosa membrane directly into the 
bloodstream. Since their discovery, cyclodextrins have been extensively
 studied as drug transport enhancers for parenteral, oral, opthalmic,
nasal, dermal, and other pharmaceutical delivery modalities (14). 
This includes the favorable delivery of sublingual testosterone 
preparations where elevations in serum testosterone lasted in excess 
of five hours, returning to baseline at the sixth hour (15). This  
mode of sublingual delivery (held under the tongue until dissolved) 
is the method by which Cyclo Diol XS is supplied to you. Because of 
the superior delivery method, less prohormone is necessary for 
achieving optimal blood plasma levels. Each sublingual lozenge 
contains a combined total of 25mg 19 Nor-4-Androstene-3,17-Diol and 
4-Androstene-3,17-Diol. 
Each bottle contains 60 lozenges. 
Item Code: Cyclo Diol XS� 
Price Per Bottle: $55.00 USD 
***BUY THREE GET ONE FREE***
Price per Case of 12 Bottles: $575.00 USD (a savings of $85.00 USD). 
SHIPPING: $3.00 for Priority Air Mail for Individual Bottles
                    $8.00 per case (includes insurance). 


NorDiol4 (19 Nor-4-Androstene-3,17-Diol): This product is converted to
the highly anabolic (muscle building), low androgenic (masculinizing) 
hormone nandrolone (10) by one of the hydroxysteroid dehydrogenase 
enzymes in vivo.(4) This hydroxylated compound gives a faster and 
higher elevation in serum nandrolone concentrations than the oxidized
version norandrostenedione. As with most 19-Nortestosterone 
derivatives, the androgenic character of nandrolone is substantially 
less than that of testosterone. (1,2,3) Each capsule contains 100mg 
19 Nor-4-Androstene-3,17-Diol. 
Each bottle contains 60 capsules.
Item Code: NorDiol4 
Price Per Bottle: $55.00 USD 
Price per Case of 12 Bottles: $575.00 USD (a savings of $85.00 USD)
***BUY THREE GET ONE FREE***
SHIPPING: $3.00 for Priority Air Mail for Individual Bottles; 
$8.00 per case (includes insurance). 

Androstenediol (4-Androstene-3,17-Diol): This intermediary of hormone 
metabolism is the most potent testosterone elevating pro-hormone on 
the market. Androstenediol provides a faster, higher elevation in 
testosterone formation than our previous best selling androstenedione.
This hydroxylated version converts to the anabolic (muscle building) & 
highly androgenic (masculinizing) hormone testosterone by the 17 beta-hydroxysteroid
dehydrogenase enzymes(4,5,6). In numerous published studies, this 
hormone has been shown to play an important role in androgen 
(testosterone) formation(7), reduction of bone turnover(8), and suppression 
of the catabolic hormone cortisol(9). Because women are more 
susceptible to side effects associated with androgen use, this product
should not be used by women. 

Each capsule contains 100mg of 4-Androstene-3,17-Diol 
Each bottle contains 60 capsules 
Item Code: Diol4 
Price per Bottle: $30.00 USD 
***BUY THREE GET ONE FREE***
Price per Case of 12 Bottles: $316.00 ($44.00 USD in savings) 
SHIPPING: $3.00 for Priority Air Mail for individual bottles
$8.00 per case includes insurance. 


Question: I am interested in your pro-hormone products, but I'm a 
little skeptical. How close do your products compare to real steroids 
and do they have the same effects as steroids? If so, how is it that 
you are able to get by the FDA in the U.S.? How toxic are your products
on the liver?

Answer: All of the pro-hormones we sell fall under the same classification 
as does DHEA. As such, they are legal for sale as a "dietary supplement" 
only. This position by the FDA may change in the future. Furthermore, 
make sure you check with your physician before starting these or any 
dietary supplements. Androstenediol is an adrenal steroid, like DHEA, 
yet is one biochemical step from being converted to testosterone.
DHEA, conversely, has an almost equal probability of being converted 
to an estrogen. The other pro hormone - the "nor" version, is a placental 
and ovarian derived hormone which lacks a methyl group (CH3) on the 
19th carbon of the steroid ring structure. This greatly reduces the 
androgenic character of the compound in comparison to the androstenediol 
version. All of the banned steroids (those which do require a prescription) 
are modified versions of testosterone and estradiol in the sense that 
alkyl groups (chains of carbon-hydrogen subunits) are added - often on 
the 17th carbon. This alkylation procedure is done generally to 
increase the time these compounds stay in the system before being excreted.
 Since the androstenediol and norandrostenediol versions do not have 
these alkyl substituents added to them, they are considered "natural". 
Whether or not theyare natural has no bearing whatsoever on the efficacy 
or the potential for side effects if abused. Take the "nor"version for 
example. This compound converts to nandrolone - a highly anabolic steroid. 
A pharmaceutical/scheduledversion of this is known as nandrolone decanoate 
(the decanoate is a term used to define the alkyl group - a repeating 
subunit primarily composed of 10 CH2 groups). This scheduled version is 
a potent anabolic steroid often used to excess by athletes, bodybuilders 
in particular. The metabolites of nandrolone decanoate are the same as 
those seen with the use of norandrostenediol. If one is tested for 
performance enhancing drugs (steroids), that person will test positive 
when using these "nor" pro-hormones - just like what happens when one 
uses the scheduled/prescription nandrolone decanoate. It has already 
happened to several athletes who unwittingly used them thinking that a
 natural supplement means "not-to-worry" about testing positive for banned 
drug use. In regards to toxicity on the liver, the only steroids, prescription 
or otherwise, that have caused a high degree of hepatocellular stress/damage 
are those which are alkylated in the alpha position as well as those which 
have halogens added as a functional group attachment(12,13). The alpha 
position refers to the alkyl group being below the plane of the molecular 
steroid ring structure, whereas beta refers to being above it. The oral 
steroids are generally an alpha-alkylated type, whereas the beta versions 
are the injectable. Halogens are those atoms in the 7th column in the 
table of the elements. An example of a halogenated prescription steroid 
would be fluoxymesterone- a fluorine atom is added as a functional group 
(yet in this case - on the 9th carbon). Since pro-hormones are not alkylated, 
in the alpha position or the beta position, their degree of hepatoxicity 
is probably far less than those which are the alkylated "prescription-only" 
type. However, we know of no studies which have determined whether or not 
pro-hormones have any negative effects on hepatic function. As such, make 
sure you check with your physician before starting these or any dietary 
supplements.

                                  ABBREVIATED REFERENCES

1. Toth M; Zakar T. Classification of anabolic steroids using the 
method of competitive metabolism. Exp Clin Endocrinol (EPA), 1986 Jul; 87 (2): 125-32.      

2. van der Vies J. Implications of basic pharmacology in the therapy with 
esters of nandrolone. Acta Endocrinol Suppl (Copenh) (ONF), 1985; 271: 38-44.      

3. Bergink EW; Janssen PS; Turpijn EW; van der Vies J. Comparison of the
 receptor binding properties of nandrolone and testosterone under in vitro 
and in vivo conditions. J Steroid Biochem (K70), 1985 Jun; 22 (6): 831-6.      

4. Labrie F; Luu-The V; Lin SX; Labrie C; Simard J; Breton R; Belanger A. 
The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology. 
Steroids(V10), 1997 Jan; 62 (1): 148-58.      

5. Andersson S; Geissler WM; Patel S; Wu L. The molecular biology of androgenic 
17 beta-hydroxysteroid dehydrogenases. J Steroid Biochem Mol Biol (AX4), 1995 Jun; 53 
(1-6):37-9.      

6. Dufau ML; Miyagawa Y; Takada S; Khanum A; Miyagawa H; Buczko E. Regulation 
of androgen synthesis: the late steroidogenic pathway. Steroids (V10), 1997 
Jan; 62 (1): 128-32.

7. Chen C; Belanger A; Labrie F. Adrenal steroid precursors exert potent androgenic
 action in the hamster sebaceous glands of flank organs and ears. Endocrinology (EGZ), 
1996 May; 137 (5): 1752-7.      

8. Lea CK; Moxham V; Reed MJ; Flanagan AM. Androstenedione treatment reduces loss of 
cancellous bone volume in ovarectomised rats in a dose-responsive manner and the
 effect is not mediated by oestrogen. J Endocrinol (I1J), 1998 Feb; 156 (2): 331-9.      

9. Wood CE; Saoud CJ. Influence of estradiol and androstenedione on ACTH and cortisol 
secretion in the ovine fetus. J Soc Gynecol Investig (CMH), 1997 Nov-Dec; 
4 (6): 279-83.      

10. Hoogenboom LA; Berghmans MC; Traag WA. Biotransformation of beta-nortestosterone 
by cultured porcine hepatocytes. J Chromatogr, 1989 Apr 7; 489(1):105-9.      

11. Killinger DW; Perel E; Daniilescu D; Kharlip L; Blackstein ME. Aromatase 
activity in the breast and other peripheral tissues and its therapeutic regulation. 
Steroids, 1987 Oct-Dec; 50 (4-6):523-36.      

12. Welder, Allison A.; Robertson, John W; Melchert, Russel B. Toxic effects of 
anabolic-androgenic steroids in primary rat hepatic cell cultures. Journal of 
Pharmacological and Toxicological Methods, 1995; 33 (4) 187-95.      

13. Ishak, KG; Zimmerman, HJ. Hepatoxic effects of the anabolic-androgenic steroids. 
Sem Liver Dis.1987, 7 (3): 230      

14. Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery. J Pharm Sci 
1996 Nov; 85(11):1142-69      

15. Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin 
in hypogonadal men: comparison to testosterone enanthate - a clinical research center study. J Clin Endocrinol Metab 1995 Dec;80(12):3567-75 



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