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Article #2117Re: Does HIV kill cells?
From: Michael Robertson
Date: Sun, 27 Mar 1994 17:53
Date: Sun, 27 Mar 1994 17:53
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2443 bytes
In regard to cell killing by HIV, it depends on the cell type that your talking about and the strain of HIV. Many strains, especially lab adapted strains like HIV-1/Lai can induce syncytia in CD4+ cells which then go on to die. However, some strains of HIV do not induce syncytia. More recenly HIV has been shown to induce apoptosis in some cell lines, like CEM cells, a CD4+ tumor cell line. However, again, not all strains of HIV do this, and the strains that do induce apoptosis in CEM cells may not do it in other cell lines. The situation in CD4+ T cells in vivo is even less clear, and it is postulated that indirect mechanisms are responsible for the depletion of CD4 cells in vivo. This is one of the most important questions in AIDS pathogenesis right now. Thus, to summarize, some strains of HIV can definitely kill directly some CD4+ cell lines, but it is not known if this direct killing is responsible for the depletion of CD4+ cells in vivo. See Robin Weiss's article in Science (1990) 260:1273-1279 for a well written summary of "How does HIV cause AIDS?" which addresses not only the issue of does HIV cause AIDS but the postulated mechanisms.
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X-Google-Language: ENGLISH,ASCII-7-bit X-Google-Thread: 107c0a,1b241de11115c682 X-Google-Attributes: gid107c0a,public X-Google-Thread: 103cc5,1b241de11115c682 X-Google-Attributes: gid103cc5,public X-Google-Thread: f8e22,1b241de11115c682 X-Google-Attributes: gidf8e22,public X-Google-Thread: 1119a6,1b241de11115c682 X-Google-Attributes: gid1119a6,public X-Google-Thread: 11045f,1b241de11115c682 X-Google-Attributes: gid11045f,public X-Google-Thread: ff2c4,1b241de11115c682 X-Google-Attributes: gidff2c4,public X-Google-ArrivalTime: 1994-03-27 09:53:21 PST Path: arc1-ca.pugleaf.net!bga.com!news.sprintlink.net!news.world.net!guardian.up.edu!sequent!uunet!yeshua.marcam.com!charnel!olivea!sgigate.sgi.com!sgiblab!cs.uoregon.edu!reuter.cse.ogi.edu!netnews.nwnet.net!news.u.washington.edu!michaelr From: michaelr@u.washington.edu (Michael Robertson) Newsgroups: bionet.general,bionet.cellbiol,bionet.molbio.hiv,bionet.virology,bionet.immunology,sci.bio Subject: Re: Does HIV kill cells? Date: 27 Mar 1994 17:53:21 GMT Organization: University of Washington, Seattle Lines: 17 Message-ID: <2n4h6h$kt@news.u.washington.edu> References: <1994Mar24.085208.16835@leeds.ac.uk> <2mrt5l$9vv@rc1.vub.ac.be> NNTP-Posting-Host: stein.u.washington.edu