Antigen Presenting cells

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1 total messages Started by j_thomas Mon, 27 Dec 2010 00:24

#151

Author: j_thomas
Date: Mon, 27 Dec 2010 00:24

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Antigen Presenting cells express both MHC molecules,in this case MHC
II molecule co stimulator molecule such as CD80.Stimulation of T cells
in this case CD4 tcell by the antigen presenting cell involves the
interaction of T cell receptor and co receptor molecule with the MHC
peptide complex.As well as the interaction between the  CD80 and
CD28.The interaction of antigen presenting cell with T cell causes
signals to pass in both direction.Signalling the antigen presenting
cell to express additional co-stimulatary molecules such as CD86 and
CD40.At the same time signals to T cell receptor and CD28 induce T
cell to express CD40L(CD40 ligand).the interaction between CD40L and
CD40 As well the additional stimulation through CD28 mediated by
interaction with CD86 resolved in full activation of CD4 T cell.

http://www.biosolutions.info/2009/06/tcr-apc-interaction.html

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