Re: equilibrium const for disulfide bond formation

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#2251

From: hanson
Date: Thu, 11 Jan 2007 04:25

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"Bob" <bbx107.XYZ@excite.XYZ.com> wrote in message
news:a49bq2lve6k3skf7thuqronoo2csh4hq3a@4ax.com...
>
[Bob]
> If you have it at fairly high concentration in an oxidizing
> environment (air), and the Cys are exposed, one would expect that.
> Solutions include keeping the conc low, avoiding oxidation -- and
> reducing the dimers back to monomers, say with mercaptoethanol.
>
[hanson]
Interesting. Are you basically telling here that the oxidized/dimer of
Cysteine, now Cystine: HOOC(NH2)C-CH2-S-S-CH2-C(NH2)COOH
together with 2 HS-CH2-CH2-OH disproportionates/redoxes into
 2 HS-CH2-C(NH2)COOH  and HO-CH2-CH2-S-S-CH2-CH2-OH.

Does HSEtOH work as a reducer for all -S-S- molecules in biologial
systems?

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From: "hanson" <hanson@quick.net>
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Subject: Re: equilibrium const for disulfide bond formation
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