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Article #49Re: Would the burn be white if its proteins did not didn't coagulate?
From: baranyi
Date: Sat, 14 Jan 2006 21:51
Date: Sat, 14 Jan 2006 21:51
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The redness and whiteness during light burns is the result of different behaviour of the subcutaneous capillaries. Heat induces shock. The resident granulocytes (histiocytes residing in the subcutaneous tissue) degranulate, and among others release histamine that is a potent vasoconstrictor. It causes the smooth muscle in the capillary to constrict. Constricted blood vessels reduce the blood flow locally, and the skin looks pale (white). This reaction is less visible in the more pigmented skin. Now if the burn is more severe, is causes tissue damage. Cells necrotize and the permeability of endothelial lining of the blood vessels increases (serum exudes) in addition to the histamines other components are released too including the components of the complement system, all of this results in a localized, but rapidly escalating inflammatory reaction. This further increases the vascular permeability, vasodilation and enhanced blood which is necessary for leucocytes to infiltrate the damaged tissue (to protect and help to repair it). At this stage erythema formation is common occurrence which is the swelling and redness of the affected areas of the skin. This takes some time to develop, so the proper order of changes is: whiteness immediately after the injury, followed by redness in minutes or hours. Now if you have a VERY strong burn, "cauterizing" burn, that coagulates proteins even deeper in the tissue, it plugs the blood vessels by causing the proteins to coagulate, there is no blood circulation, and the skin remains pale (white). Because of reduced circulation, it takes much longer for the inflammatory reaction to begin and usually the injury develops a decently sized "sack" filled with yellowish plasma that hides any color below it (plain optical phenomenon) it protects the underlying tissue but dries up gradually and normal blood coagulation proteins help to form a brownish cover over the damaged area. The ultimate burn injury results in charring. Charred tissue is initially a dry mixture of skin proteins and blood, contains large amount of carbohydrates, lipids, hemoglobins etc, and all kind of degradation products thereof, carbonized, caramelized sugars etc, that causes it to have a dark almost black color. It never regenerates (dead tissue), but easily breaks and allows bacteria to seep into the wounds. charred tissue is usually removed to hasten the healing. lajos
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