Thread View: sci.med.pharmacy
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Started by bernd rupp
Fri, 23 Aug 1996 00:00
I1 recetor agonists
Author: bernd rupp
Date: Fri, 23 Aug 1996 00:00
Date: Fri, 23 Aug 1996 00:00
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Dear all, who knows the pKa value of rilmenidine, azepexole and ganfacin? Thanks for help -- Bernd Rupp | Institut fuer Pharmazeutische Chemie | Heinrich-Heine-Universitaet Duesseldorf phone +49 211-811 36 62 | Universitaetsstr. 1, Geb. 26.23 fax +49 211-811 38 47 | 40225 Duesseldorf rupp@pharm.uni-duesseldorf.de
Re: I1 recetor agonists
Author: Ian Musgrave
Date: Mon, 26 Aug 1996 00:00
Date: Mon, 26 Aug 1996 00:00
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G'Day All
bernd rupp <rupp@pharm.uni-duesseldorf.de> writes:
>From: bernd rupp <rupp@pharm.uni-duesseldorf.de>
>Subject: I1 recetor agonists
>Date: 23 Aug 1996 21:50:18 -0700
>Dear all,
>who knows the pKa value of rilmenidine, azepexole and ganfacin?
>Thanks for help
For I1 receptors? In what tissue? I don't think anyone has a Ka for these
substances, I can give you Ki's though.
Ki (nM)
Drug Adrenal Medulla Bovine RVLM
azepexole ND 1140
guanafacine ND 2500
rilmenidine 84 6
ND=not determined
A big problem in this field is that rarely do two different investigators use
the same panel of imidaoline/ oxazoline /guanadinium compounds.
Hope this helps, cheers Ian
---------------------------------------------
Ian Musgrave Ph.D, Prince Henry's Institute of Medical Research
PO Box 5152, Clayton 3168, Australia.
Phone +61 3 550 4286 FAX +61 3 550 6125
Lab: Ian.Musgrave@med.monash.edu.au <http://www.mmcc.monash.edu.au/~ian-mu/>
Private: Reynella@werple.mira.net.au <http://werple.mira.net.au/~reynella/>
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