🚀 go-pugleaf

-----------------------------------
Postdoctoral position as posted on Postdoc Jobs website:

http://www.PostdocJobs.com
-----------------------------------

Postdoctoral Fellowship in Yeast Molecular Genetics,NIH, Bethesda,
Maryland

Postdoctoral position is available immediately to study mechanisms of
gene regulation in yeast. Genetics, molecular biology and biochemistry
are employed to determine how the activator protein GCN4 stimulates
transcription of ~1000 genes, including amino acid biosynthetic genes,
in nutrient-deprived cells (Mol Cell Biol 21:4347). We are identifying
specific subunits of the RNA polymerase mediator, CCR4/NOT and the
SAGA, SWI/SNF and RSC chromatin remodeling complexes required for
transcriptional activation by GCN4 in vivo (eg. Mol Cell 4:657). A
structure/function analysis of key subunits is being initiated,
focusing on those necessary for recruitment of the coactivator complex
to the promoter through direct interaction with GCN4.

GCN4 expression is regulated at the translational level and we also
investigate the structure and function of translation initiation
factors (eIFs) and protein kinases involved in this regulatory
mechanism (eg. Genes Dev 14: 2534). Major goals include the
identification of molecular interactions among initiation factors
involved in the assembly of 48S preinitiation complexes (with emphasis
on eIF2 and eIF3) and genetic analysis of the importance of these
interactions for translation initiation in vivo. The protein kinase
GCN2, which induces GCN4 translation by phosphorylation of eIF2, is
under intensive study to determine how its kinase function is
activated by deacylated tRNAs in amino acid-starved cells (eg. Mol
Cell 6:269) and in other stress conditions.

Applicant must have a Ph.D. or M.D. and less than five years of
postdoctoral experience. Non-U.S. citizens will be supported on a J-1
visa only. Starting salary of $30,000.
NIH is an equal opportunity employer.

Interested applicants should submit a CV, bibliography, a cover letter
with a brief description of research experience and interests, and the
names of three references with phone numbers and email addresses.

--------------------------
For more information, please visit PostdocJobs website

http://www.PostdocJobs.com

---------------------------