🚀 go-pugleaf

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Postdoctoral position as posted on Postdoc Jobs website:

http://www.PostdocJobs.com
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The type 6 cGMP phosphodiesterases (PDE6) are essential enzymes in the
phototransduction process in rod and cone photoreceptor cells. We are
using varied approaches including promoter characterization in
transgenic animals and tissue culture cells, subunit expression with
recombinant adenovirus, and structural studies of purified enzyme to
understand fundamental processes involving PDE6 in photoreceptor
cells. We plan to develop an expression system for the enzyme, to
determine the basis for photoreceptor-specific expression, and to
unravel the basis for the enzymes complex assembly.

We are also working on a knockout of an ion channel gene. Recently it
was reported that patients with a defect in this channel subunit
exhibit typical retinitis pigmentosa. Our goal is to develop and
characterize the knockout and then to introduce point mutants back
using standard mouse transgenesis.

The successful candidate will have a Ph.D. degree with experience in
molecular biology, cell biology, biochemistry or related disciplines.
The laboratory is ~2000 sq. ft. of newly renovated space that is fully
equipped for the proposed studies. There are currently three active
grants supporting 7 students, fellows, and research technicians in the
laboratory. The research environment is further enhanced by
exceptional core facilities in the Vision Science Research Center and
an outstanding imaging facility.

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For more information, please visit PostdocJobs website

http://www.PostdocJobs.com

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