🚀 go-pugleaf

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Postdoctoral position as posted on Postdoc Jobs website:

http://www.PostdocJobs.com
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Immediately available, NIH-funded position for Ph.D. to study
molecular and cellular biology of parathyroid hormone (PTH) action in
osteoblasts and preosteoblastic marrow stromal cells. PTH recently was
introduced as a powerful therapeutic for osteoporosis, but its
mechanism of action is poorly understood. Our work focuses on the
individual roles of multiple signals generated by PTH/PTHrP receptors
in regulating gene expression, differentiation and distal biologic
function in bone cells involved in formation vs. resorption of bone.
Receptor and ligand mutagenesis are combined with use of conditionally
transformed clonal bone and marrow cell lines from PTH/PTHrP receptor
knock-out mice to discern roles of specific signaling events in
triggering key cellular responses to PTH. Experience with mammalian
cell transfection and culture, single-cell fluorescence,
radioimmunoassay, cDNA cloning, Northern and Western blotting, RT-PCR,
in-situ hybridization, microarray analysis and reporter gene
regulation desirable but not required.

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For more information, please visit PostdocJobs website

http://www.PostdocJobs.com

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